HLA in Health and Disease
Robert Lechler, Anthony N. Warrens
Academic Press, 2000 - Medical - 472 pages
This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference.
The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing.
HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry.
* Structure, function and genetics of HLA
* HLA nomenclature
* Evolution of HLA polymorphisms
* HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry
* HLA and organ transplantation
* Serological and PCR-based methods in HLA typing
* Cellular techniques in testing histocompatibility
* Edited and written by an international panel of experts in the field
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The History of the Discovery of HLA
The Structure of the Major Histocompatibility Complex and
Molecular Genetics of the Human Major Histocompatibility Complex
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Other editions - View all
allogeneic allograft amino acid analysis anti antibodies arthritis asso autoantibodies autoimmune Behcet's Behcet's disease binding Caucasoid CD4+ cell responses chromosome chronic class II alleles class II molecules Clin clinical clones coeliac disease cytotoxic diabetes disease donor DQB1 DRB1 encoded epitopes expression factors frequency function genetic genome Goodpasture's disease graft haplotype hepatitis HLA alleles HLA antigens HLA associations HLA class HLA molecules HLA typing HLA-A HLA-B HLA-DR human immune response Immunogenetics Immunol infection interaction Japanese kidney leucocyte linkage disequilibrium loci locus lymphocytes major histocompatibility complex markers MHC class MHC molecules mice molecular molecules Natl Acad pathogens patients peptide peptide-binding phenotype polymorphism population positive presentation Proc proteasome protein receptor region relative risk renal residues Rheum role sequence serological significant specific susceptibility syndrome systemic lupus erythematosus tapasin thyroiditis tion Tissue Antigens transplantation uveitis viral virus