Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Front Cover
Springer Science & Business Media, Dec 31, 2001 - Medical - 291 pages
2 Reviews
In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.
 

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Contents

I
1
II
3
III
4
V
6
VI
7
VII
8
IX
18
X
28
XCIV
129
XCV
132
XCVI
133
XCVIII
134
XCIX
135
C
137
CI
140
CII
141

XI
29
XII
31
XIV
33
XVI
35
XVII
37
XVIII
38
XX
40
XXI
41
XXII
44
XXIII
45
XXV
46
XXVI
47
XXVII
54
XXVIII
66
XXIX
67
XXX
68
XXXIII
69
XXXIV
70
XXXVI
71
XXXVII
73
XXXVIII
74
XXXIX
75
XLI
76
XLIII
79
XLIV
80
XLVII
81
XLIX
82
LI
83
LII
85
LIII
86
LVI
87
LVII
89
LVIII
94
LIX
95
LX
98
LXI
99
LXIII
100
LXVII
101
LXVIII
102
LXX
103
LXXI
105
LXXII
107
LXXIII
109
LXXIV
110
LXXV
111
LXXVI
112
LXXVIII
114
LXXIX
115
LXXXII
116
LXXXIII
117
LXXXV
118
LXXXVII
119
XC
121
XCI
122
XCII
123
CIII
142
CIV
143
CV
145
CVII
146
CXI
149
CXII
151
CXIII
154
CXV
158
CXVII
160
CXVIII
161
CXIX
162
CXXI
163
CXXIII
164
CXXV
165
CXXVIII
169
CXXIX
170
CXXX
171
CXXXII
173
CXXXIII
175
CXXXIV
176
CXXXVI
177
CXXXVII
178
CXL
179
CXLI
180
CXLII
181
CXLIV
182
CXLV
185
CXLVI
186
CXLIX
187
CLII
188
CLIII
189
CLIV
190
CLV
191
CLVI
192
CLVII
193
CLX
194
CLXI
198
CLXIII
199
CLXIV
200
CLXV
203
CLXVI
204
CLXVII
207
CLXVIII
211
CLXIX
212
CLXX
227
CLXXI
228
CLXXII
229
CLXXIII
238
CLXXIV
241
CLXXV
273
CLXXVI
278
CLXXVII
279
CLXXVIII
282
CLXXIX
287
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