Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas: Molecular Genetics: Liver and Pancreatic Carcinomas, Volume 3

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M. A. Hayat
Academic Press, Sep 21, 2005 - Science - 432 pages
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Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer.

This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today.

* The only book available that translates molecular genetics into cancer diagnosis
* The results of each Immunohistochemical and in situ hybridization method are presented in the form of color illustrations
* Methods discussed were either developed or refined by expert contributors in their own laboratories
 

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Contents

Chapter 1 Introduction
1
Chapter 2 Genetic integrity DNA repair and recombination
3
Chapter 3 Replication error RER and genetic instability
24
Chapter 4 DNA repeats genetic recombination and the pathogenesis of genetic disorders
41
Chapter 5 Chromosomal recombination in cancer
67
Chapter 6 Chromosomal translocation and its phenotypic effects
76
Chapter 7 DNA methylation and genetic instability
133
Chapter 8 Telomeric DNA and genetic instability
154
Epilogue
164
References
170
Index
237
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Page 233 - Kerr, JFR, Wyllie, AH, and Currie, AR (1972) Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics.

About the author (2005)

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

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