Handbook of Physiology: Section 2: The Cardiovascular System Volume I: The Heart
An American Physiological Society Book, Dec 15, 2001 - Medical - 848 pages
This volume continues the tradition of thoughtful, in-depth examination of critical subjects in the Handbook of Physiology, though the molecular revolution has transformed cardiovascular research from a stable, mature field into one that is exploding with new findings. The 21 chapters were written by outstanding international investigators in the fields of cell structure, muscle contraction and control, and electrophysiology. They cover basic molecular events but highlight the strong relationships to physiological processes that will soon be important in cardiovascular disease. In the discussions of structure, the emphasis is on normal and abnormal growth as well as the dynamic properties of cell communication via gap junctions. Muscle function is explored from actin-myosin molecular interactions to control of intracellular calcium and contraction by its principal transporters. The book shows how cardiac electrophysiology integrates the whole heart from cellular action potentials and conduction to mathematical models. Current concepts of ion channel structure and function and the heterogeneous distribution and expression of these channels are detailed. The heart as a malfunctioning organ is considered in chapters on arrhythmias, ventricular function, and heart failure. The chapters are extensively referenced and focus on the critical questions in basic cardiology for physiologists to address in the future, drawing on the power of molecular studies and the genome map.
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Robert S Kass Ph D John P Schroeter Ph D
Molecular Analysis of VoltageGated K+ Channel Diversity
Ultrastructure of the Heart 3
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actin action potential activation Anversa artery ATPase atrial Biochem Biophys Ca2+ binding Ca2+-ATPase calcium capillary cardiac muscle cardiac myocytes cardiac sarcoplasmic Cardiol caveolae caveolin cellular changes Chem Circ conduction connexins contractile coronary crossbridge cTnl cycle cytoplasmic cytosol decrease diac domain effects electron excitation function gap junction gap junction channels gene Heart Circ hypertrophy inactivation increase infarction inhibition interaction intracellular ionic isoforms isolated kinetics light chain Lond longitudinal mammalian mechanism microscopy mitochondria MLC2 molecular molecules muscle cells mutant myocardial myocardium myocyte cell myofibrils myofilament myosin Na/Ca exchange Na+-Ca2+ exchange neurons node phospholamban phosphorylation Physiol physiological plasma membrane propagation protein kinase rabbit receptor region regulation regulatory release role sarcolemmal sarcomere sarcoplasmic reticulum skeletal muscle sodium-calcium exchange spiral wave stimulation structure studies tension thin filament tion tissue titin transient transmembrane transport tropomyosin troponin vagal velocity ventricle ventricular myocytes voltage wavefront Z-band