Handbook of Venoms and Toxins of Reptiles

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Stephen P. Mackessy
CRC Press, Apr 19, 2016 - Nature - 528 pages
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The Handbook of Venoms and Toxins of Reptiles offers "one-stop shopping" to all biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, and informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation. This book examines the topic generally, provides an overview of the current taxonomy of these reptiles, explains the similarities and differences in the venom delivery apparatus in different groups of reptiles, reviews state-of-the-art knowledge about specific venom components and their action, and summarizes effects of envenomation and treatment in humans on different continents.

Produced by leading toxinologists, biologists, biochemists, and physicians from 12 countries, the book provides a broad, international perspective that bridges divergent areas in modern biology. A synthesis of current knowledge about venoms and venomous reptiles, it contains a wealth of illustrations, including an 8-page color insert, that present a view of reptile toxinology from the whole animal to the glands producing venoms to the molecular models and the mechanisms of actions of the toxins themselves.

The book provides a context for understanding the range of activities present in venoms and supplies detailed information on many enzymes and toxins found in them, bringing into focus the worldwide extent of the occurrence and complexity of human envenomations by reptiles. It explores the unique and interesting results produced by collaborations between specialists from very different fields and how they can stimulate new and continued interest in research on venoms and the animals that produce them.

 

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Contents

Snakes Lizards and Their Venoms
3
Chapter 2 Recent Advances in Venomous Snake Systematics
25
From Function and Future
65
Reptile Venom Enzymes
93
Chapter 4 Snake Venom Metalloproteinases
95
Biological Roles and Participation in the Pathophysiology of Envenomation
115
Chapter 6 ThrombinLike Snake Venom Serine Proteinases
139
Chapter 7 Snake Venom Nucleases Nucleotidases and Phosphomonoesterases
155
Chapter 14 Sarafotoxins the Snake Venom Homologs of the Endothelins
303
Toxins from Mamba Venoms That Inhibit Acetylcholinesterase
317
Chapter 16 CysteineRich Secretory Proteins in Reptile Venoms
325
Portrait and Evolution of a Family of Snake Venom Integrin Antagonists
337
Chapter 18 Reptile CType Lectins
359
Chapter 19 Snake Venom Nerve Growth Factors
377
Chapter 20 The Role of Purine and Pyrimidine Nucleosides in Snake Venoms
393
Envenomation Occurence Prevention Treatment
421

Chapter 8 Snake Venom Phospholipase A2 Enzymes
173
Chapter 9 Snake Venom Acetylcholinesterase
207
Chapter 10 Snake Venom LAmino Acid Oxidases
221
Beyond a Spreading Factor
237
Innate Immunity to Snake Venoms
259
Reptile Venom Toxins
285
Chapter 13 Snake Venom ThreeFinger Toxins
287
Prevention and Treatment in Australia
423
Current Situation and Urgent Needs
453
Chapter 23 Envenomations by Reptiles in the United States
475
Chapter 24 Snakebite Envenomation in Central America
491
Index
509
Back cover
531
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About the author (2016)

Stephen P. Mackessy is currently professor of biology in the School of Biological Sciences at the University of Northern Colorado (UNC). His research broadly encompasses the biology of venomous snakes and the biochemistry of snake venoms, and he has published over one hundred scientific papers, book chapters, and natural history notes.

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