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Secretion of Insulin
Theoretical Models for Insulin Secretion
B Insulin Synthesis in BCells
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131I insulin Acta Amst action of insulin adenylate cyclase adipose tissue alloxan Amer amino acids arginine Ashcroft B-cell binding Biochem biol biological activity biophys biosynthesis C-peptide calcium cAMP cell membrane Chem clin Cuatrecasas cyclic AMP degradation diabetic ribosomes effect of insulin Endocr Endocrinology enzyme fat cells fatty acids fraction gastric gastrin glucagon glucose metabolism glycogen granules Grodsky Hellerstrom Hellman hormone hypoglycemia increased incubated inhibition inhibitors injection insulin receptor insulin release insulin secretion intracellular intravenous islet cells islets of Langerhans isolated islets isolated perfused isolated rat kidney leucine levels Lond Malaisse mannoheptulose Matschinsky mechanism metabolism molecule mouse muscle normal and diabetic nucleotide observed oxidation pancreatic islets peptide perfused rat Physiol plasma membrane Proc proinsulin protein synthesis puromycin pyruvate radioactivity Randle rat liver rat pancreas regulation response ribosomes role secretory serum specific Steiner stimulation studies substrate sugar sulfonylureas Taljedal theophylline tolbutamide trichloroacetic acid uptake vitro vivo