Handbook of Pharmaceutical Granulation Technology

Front Cover
Dilip M. Parikh
CRC Press, Jun 17, 1997 - Medical - 528 pages
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Integrating the basic principles and industrial practices of pharmaceutical granulation production, this book discusses technologies and demonstrates cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements. Specialists from pharmaceutical companies, academia, and the U.S. Drug Regulatory Affairs agency address current and changing practices in industrial drug granulation production. Text, charts, figures, and photographs illustrate the pros and cons of diverse methods and technologies for accurately achieving strong bonding of particles in tablets and capsules.
 

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Contents

INTRODUCTION
26
Drug Substance and Excipient Characterization
29
SOLUBILITY
39
CRYSTAL PROPERTIES AND POLYMORPHISM
46
4
60
Binders and Solvents
65
FACTORS INFLUENCING BINDER EFFICIENCY
67
Shaw
76
SinglePot Processing
303
ExtrusionSpheronization as a Granulation Technique
333
Continuous Granulation
369
Sizing of Granulation
389
Methods and Significance
419
Bioavailability and Granule Properties
471
II
484
Regulatory Issues in Granulation Processes
485

Roller Compaction Technology
99
High Shear Mixer Granulators
151
REFERENCES
200
Batch Fluid Bed Granulation
227

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