Heart Development, Volume 342
Richard P. Harvey, Nadia Rosenthal
Academic Press, 1999 - Medical - 530 pages
The development of the cardiovascular system is an exciting and rapidly advancing area of biomedical research, powered by an urgent necessity to reduce the incidence of human cardiovascular disease. It is becoming increasingly clear that many of the congenital pathologies affecting the adult heart will be best understood by tracing their origins in embryonic development. The recent fusion of classical embryology with modern molecular genetics has resulted in an explosion of information about the developing heart in a variety of organisms. A comprehensive knowledge of the control circuitry in the cardiovascular system will form the basis for future advances in genetic therapy and organ culture. Heart Development presents a collection of chapters written by experts in the field, who describe their current insights into the molecular basis of cardiovascular development. The subject matter from the lineage origins and morphogenesis of the developing cardiovascular system, through genetic dissection of cardiovascular development in a variety of model organism, to the molecular basis of congenital heart defects. Its broad scope will appeal to the generalist or teacher seeking an overview of the subject, while also providing clinicians and medical researchers with comprehensive coverage of the most recent advances.
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Ill Fate Maps of Cardiac Tissues
Patterning and Cell Commitment to
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activity angiogenesis aortic arteries asymmetry atrial atrioventricular atrium avian axis bhLH binding Biol Bodmer cardiac development cardiogenesis cardiogenic Cell Cambridge cell lineages Chen chick embryo defects derm Development Cambridge developmental diac differentiation domain dorsal Drosophila early ectoderm eHAND embryogenesis embryos endocardial endoderm endothelial cells epiblast explants fate map function gastrulation gene expression Genes Dev genetic growth factor heart development heart field heart looping heart mesoderm heart tube homeobox gene homeodomain induction interactions Jacobson markers MCAT MEF2 ment mice midline migration molecular Molkentin morphogenesis mouse embryo murine muscle cells mutant myocardial myocardium myogenic myosin Nature London neural crest normal notochord Olson pathway phenotype precursors primitive streak progenitors protein Purkinje fibers Randomized heart receptor region regulation right ventricle role segments signaling skeletal smooth muscle specification Srivastava stage Stainier studies tinman tion tissue transcription factor transgenic vascular vasculogenesis ventral ventricular vertebrate vessels visceral VSMCs Xenopus zebrafish