Hedgehog Signaling

Front Cover
Gerald Litwack
Academic Press, 2012 - Science - 534 pages
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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hedgehog signaling.



  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field
 

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Contents

Noncanonical Hedgehog Signaling
55
Gli Protein Nuclear Localization Signal
73
Mammalian Homologues of Drosophila Fused Kinase
91
Identification Functional Characterization and Pathobiological Significance of GLI1 Isoforms in Human Cancers
115
GliSimilar Proteins
141
Sonic Hedgehog Regulates Wnt Activity During Neural Circuit Formation
173
HedgehogGli Control by UbiquitinationAcetylation Interplay
211
Palmitoylation of Hedgehog Proteins
229
A New Era for an Ancient Drug
333
Aberrations and Therapeutics Involving the Developmental Pathway Hedgehog in Pancreatic cancer
355
Sonic Hedgehog Signaling and Potential Therapeutic Indications
379
Sonic Hedgehog on Microparticles and Neovascularization
395
Patching up the Neurons Revival or Enervation?
439
Activation of Hedgehog Pathway in Gastrointestinal Cancers
461
The Role of Sonic Hedgehog as a Regulator of Gastric Function and Differentiation
473
Sonic HedgehogMediated Synergistic Effects Guiding Angiogenesis and Osteogenesis
491

Phosphorylation Regulation of Hedgehog Signaling
253
Protein Kinase A Activity and Hedgehog Signaling Pathway
273
Phosphorylation of Gli by cAMPDependent Protein Kinase
293
ZFP932 Suppresses Cellular Hedgehog Response and Patched1 Transcription
309
Hedgehog Inhibition as an AntiCancer Strategy
507
Index
523
Colour plate
535
Copyright

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About the author (2012)

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote "Human Biochemistry and Disease" a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, "One-Eighty".

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