Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches

Faramarz Naeim, P. Nagesh Rao, Wayne W. Grody

Academic Press, Mar 5, 2009 - Science - 612 pages

This comprehensive, full color hematopathology reference book emphasizes immunophenotpic features, cytogenetic studies, and diagnostic molecular aspects. Hematopathology begins with introductions to morphologic evaluation of the hematopoietic tissues and principles of immunophenotyping, cytogenetics and molecular studies followed by chapters dedicated to different types of hematologic disorders. Each chapter starts with a basic overview of hematopathlogy followed by a comprehensive review of immunophenotypic, cytogenetic and molecular findings. The text is balanced with large numbers of full color images, graphs, charts, and tables to assist the reader in understanding these highly technical issues. - Emphasizes the immunophenotypic features, cytogenetic studies, and diagnostic molecular aspects of hematology - Features hundreds of images, charts and tables for the identification of hematologic disorders not only based on histopathologic features, but also with the use of advanced accessory techniques

Contents

• Chapter 1 Structure and Function of Hematopoietic Tissues: 1
• Chapter 2 Principles of Immunophenotyping: 27
• Chapter 3 Principles of Cytogenetics: 57
• Chapter 4 Principles of Molecular Techniques: 65
• Chapter 5 Morphology of Abnormal Bone Marrow: 81
• Chapter 6 Reactive Lymphadenopathies: 101
• Chapter 7 Bone Marrow Aplasia: 115
• Chapter 8 Myelodysplastic Syndromes: 129
• Chapter 9 Chronic Myeloproliferative Diseases: 155
• Chapter 10 MyelodysplasticMyeloproliferative Diseases: 191
• Chapter 11 Acute Myeloid Leukemia: 207
• Chapter 12 The Neoplasms of Precursor Lymphoblasts: 257
• Chapter 13 Acute Leukemias of Ambiguous Lineage: 279
• General Considerations: 287
• Chapter 15 Mature BCell Neoplasms: 297
• Chapter 16 Plasma Cell Myeloma and Related Disorders: 373
• Chapter 17 Mature Tcell and NKCell Neoplasms: 397
• Chapter 18 Hodgkin Lymphoma: 441
• Chapter 19 Nonneoplastic and Borderline Lymphocytic Disorders: 455
• Chapter 20 Mastocytosis: 477
• Chapter 21 Histiocytic and Dendritic Cell Disorders: 489
• Chapter 22 Granulocytic Disorders: 513
• Anemias: 529
• Chapter 24 Disorders of Megakaryocytes and Platelets: 567
• Index: 583

About the author

Dr. Faramarz Naeim is Professor Emeritus of Pathology, David Geffen School of Medicine, UCLA. He graduated from Tehran University School of Medicine and received his training in Pathology at Mallory Institute of Pathology, Boston City Hospital and Department of Pathology at UCLA School of Medicine. He has provided clinical services as a hematopathologist for 43 years, 30 years at UCLA, Department of Pathology and Laboratory Medicine, and 13 years at VA Greater Los Angeles Healthcare System, Department of Pathology and Laboratory Medicine. Dr. Naeim has published several books and book chapters in hematopathology and numerous articles in peer review journals.Dr. Rao is an established Elsevier author. Current projects include analysis of cytogenetic abnormalities in Paget's disease patients and analyzing the mouse karyotypes for identifying XXY males among the offspring of female chimeras from embryonic stem-cells. His cytogenetics laboratory is a training site for interested residents, fellows and medical students.Wayne W. Grody, M.D., Ph.D. is a Professor in the Departments of Pathology & Laboratory Medicine, Pediatrics, and Human Genetics at the UCLA School of Medicine. He is the director of the Diagnostic Molecular Pathology Laboratory within the UCLA Medical Center, and is also an attending physician in the Department of Pediatrics, specializing in the care of patients with or at risk for genetic disorders. He has been one of the primary developers of quality assurance and ethical guidelines for DNA-based genetic testing for a number of governmental and professional agencies including the FDA, AMA, CAP, ACMG, ASHG, NCCLS, CDC, NIH-DOE Human Genome Project (ELSI program), and PSRGN. He served as a member of the NIH-DOE Task Force on Genetic Testing, and was the working group chair for development of national guidelines for cystic fibrosis and factor V-Leiden mutation screening. Most recently, he was appointed chair of an Advisory Committee on Genomic Medicine for the entire VA healthcare system. He did his undergraduate work at Johns Hopkins University, received his M.D. and Ph.D. at Baylor College of Medicine, and completed residency and fellowship training at UCLA. He is double board-certified by the American Board of Pathology (Anatomic and Clinical Pathology, Molecular Genetic Pathology) and the American Board of Medical Genetics (Clinical Genetics, Molecular Genetics, and Biochemical Genetics).

Bibliographic information

• Title: Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches; Medicine and Dentistry 2009 : Subject Collection
• Authors: Faramarz Naeim, P. Nagesh Rao, Wayne W. Grody
• Publisher: Academic Press, 2009
• ISBN: 0080919480, 9780080919485
• Length: 612 pages
• Subjects: Science / Life Sciences / Human Anatomy & Physiology