Heme Oxygenase in Biology and Medicine

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Nader G. Abraham, Jawed Alam, Karl Nath
Springer Science & Business Media, Aug 31, 2002 - Medical - 515 pages
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Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.
 

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Contents

DEVELOPMENT OF HEME OXYGENASE INHIBITORS FOR THE PREVENTION OF SEVERE JAUNDICE IN INFANTS
3
CARBON MONOXIDE A Potential AntiInflammatory Agent and Mediator of Lung AntiOxidant Defenses
19
CORRELATION OF THE ALTERED VASCULAR EFFECTS OF CARBON MONOXIDE AND THE CARDIOVASCULAR COMPLICATIONS OF D...
31
ENDOGENOUS CARBON MONOXIDE HAS PROTECTIVE ROLES IN NEOINTIMAL DEVELOPMENT ELICITED BY ARTERIAL INJURY
43
END TIDAL BREATH CARBON MONOXIDE ETCO LEVELS IN PREGNANT WOMEN
55
THE ROLE OF HEME OXYGENASE IN PREGNANCY
67
INCREASED CARBON MONOXIDE IN EXHALED AIR IN PATIENTS WITH INFLAMMATORY RESPIRATORY DISEASES
83
CARBON MONOXIDE AND IRON BY PRODUCTS OF HEME OXYGENASE MODULATE VASCULAR ENDOTHELIAL GROWTH FACTOR S...
97
ATHEROGENICITY OF HYPERCHOLESTEROLEMIA IN THE PRECENSE OF HEMOLYSIS IN SPITE OF HEME OXYGENASE1 INDUCTION
279
ANTIATHEROGENIC PROPERTIES OF HEME OXYGENASE
293
HEME OXYGENASE AND THE NOVEL TUMOURSPECIFIC ANTIVASCULAR COMPOUND COMBRETASTATIN A4PHOSPHATE
303
THE HEME OXYGENASECARBON MONOXIDE SYSTEM IN HEPATOBILIARY PATHOPHYSIOLOGY
313
HUMAN HEME OXYGENASE HO1 DEFICIENCY AND THE OXIDATIVE INJURY OF VASCULAR ENDOTHELIAL CELLS
325
HEME OXYGENASE INDUCTION IN LIVER CELLS BY HEPATOCYTE GROWTH FACTOR AND OXIDATIVE STRESS
335
RESPONSE OF HEME OXYGENASE AND TELOMERASE ENZYMES TO OXIDATIVE STRESS IN HUMAN HEPATOMA CELL LINE HepG2
343
THE INFLUENCE OF GLUCURONIDATION ON IN VITRO ASSESSMENT OF BILIRUBIN PRODUCTION AS MEASURE OF HO ACTIVITY
353

CO AND NEONATAL CEREBRAL CIRCULATION
111
DIFFERENTIAL EXPRESSION OF HEME OXYGENASE1 IN RAT BRAIN BY ENDOTOXIN LPS
121
ROLE OF HEME CATABOLISM IN NEURODEGENERATIVE DISEASES
135
HEME OXYGENASE1 AND ALZHEIMER DISEASE
145
EARLY MOLECULAR MECHANISMS FOR THE INDUCTION OF NEURONAL MEMBRANE ASYMMETRY AND GENOMIC DNA CLEAVAGE
157
HEME OXYGENASE HO1 EXPRESSING MACROPHAGESMICROGLIAL CELLS ACCUMULATE DURING OLIGODENDROGLIOMA PROGR...
169
HEME OXYGENASE AND OCULAR SURFACE INFLAMMATION
183
TARGETED EXPRESSION OF HEME OXYGENASE1 AND PULMONARY RESPONSES TO HYPOXIA
193
HEME OXYGENASE IN SKELETAL MUSCLE
205
HEME OXYGENASE1 HO1 Multiple Effects of a Protective Gene that Prevents Graft Rejection
215
THIOREDOXIN FACILITATES THE INDUCTION OF HEME OXYGENASE1 IN RESPONSE TO INFLAMMATORY MEDIATORS
227
INDUCTION OF HEME OXYGENASE1 AS A PROTECTIVE RESPONSE AGAINST HEME PROTEININDUCED RENAL INJURY
241
REGULATION AND ROLE OF HEME OXYGENASE1 IN GLOMERULONEPHRITIS
251
HEME OXYGENASE1 MEDIATES ATRIAL NATRIURETIC PEPTIDE INDUCED PROTECTION OF RENAL CELLS FROM CYCLOSPORIN TO...
259
HEME OXYGENASE AND ATHEROSCLEROSIS
269
MOLECULAR MECHANISM OF HEME OXYGENASE1 GENE INDUCTION BY ACTIVATION OF THE PROTEIN KINASE ADEPENDENT SIG...
365
REGULATION OF HEME OXYGENASE1 GENE TRANSCRIPTION VIA THE STRESSRESPONSE ELEMENT
377
HEME OXYGENASE1 A Major Player in the Defense Against the Oxidative Tissue Injury
387
HEME OXYGENASE GINKGO BILOBA EXTRACT AND ITS TERPENOIDS PROTECT MYOCYTES AGAINST OXIDATIVE INJURY
399
TOBACCOSMOKEINDUCIBLE HUMAN HEME OXYGENASE1 GENE EXPRESSION
409
DOPPEL PROTEIN EXPRESSION CORRELATES WITH HEME OXYGENASE 1 AND NITRIC OXIDE SYNTHASE INDUCTION
423
GENERATION OF NITRIC OXIDE AND CARBON MONOXIDE PROVIDE PROTECTION AGAINST CARDIAC ANAPHYLAXIS
431
HEME OXYGENASE1 INHIBITS VASCULAR SMOOTH MUSCLE CELL PROLIFERATION
439
INDUCTION OF APOPTOSIS IN VASCULAR SMOOTH MUSCLE CELLS BY HEME OXYGENASE1DERIVED CARBON MONOXIDE
449
ROLE OF HEME OXYGENASE IN ANGIOGENESIS AND RENAL CARCINOMA
459
ON THE PROMOTING ACTION OF TAMOXIFEN IN THE P DIMETHYLAMINOAZOBENZENE INDUCED HEPATOCARCINOGENESIS CF1 ...
469
HUMAN HEME OXYGENASE GENE TRANSFER PROMOTES BODY GROWTH AND NORMALIZES BLOOD PRESSURE IN SPONTANEOUS...
481
INDEX
495
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