Hepatitis B and C: Management and Treatment
Chronic hepatitis B and C affect 520 million people worldwide, and are a major cause of chronic liver disease and of mortality, despite the efficacy of the vaccine. Hepatitis B and C: Management and Treatment second edition provides a practical explanation of the natural history and management of the disease, and examines the benefits of the most recent drugs, and their effects, whether used in isolation or as part of a combination therapy. This second edition expands the coverage of treatment of various difficult-to-treat patients and will be a welcome guide to the physician in both clinical decision-making and in explaining the benefits and side-effects to the patient.
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24 weeks 48 weeks activity grades acute hepatitis Adapted adefovir adefovir dipivoxil adverse events anemia antigen antiviral Arthralgia assess associated AUROC baseline biochemical markers chronic hepatitis cirrhosis clinical coinfected combination therapy combination with ribavirin comparison cryoglobulinemia diagnosis dose effect endpoints extrahepatic manifestations factors fibrosis progression rate fibrosis stage Figure genotype HBeAg seroconversion HBsAg HBV DNA HBV infection HBV-DNA levels HCV RNA hepatitis B infection hepatitis B virus hepatocellular carcinoma Hepatol Hepatology Hepatology 1999 Hepatology 2002 histologic interferon alfa interferon alfa-2b interferon and ribavirin lamivudine liver biopsy liver disease liver fibrosis liver transplantation long-term METAVIR monotherapy mortality natural history necroinflammatory nonresponders normal transaminases Number patients infected patients with chronic patients with genotype PEG-IFN alfa-2b Peginterferon placebo Poynard prevalence progression to cirrhosis randomized trials Ratziu reduction relapse replication ribavirin risk seroconversion serum standard interferon sustained response symptoms Table treatment of chronic undetectable viral hepatitis viral load virus infection