Hepatitis C Virus Disease: Immunobiology and Clinical Applications

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Emilio Jirillo
Springer Science & Business Media, Nov 20, 2007 - Medical - 308 pages
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Despite numerous hepatitis C virus infection studies, its pathogenesis and medical treatment have not been fully explained. This comprehensive volume, written by experts in the field, covers the most recent advances in the study of HCV, moving from basic research to clinical applications. The first chapters of this volume analyze the full spectrum of immune responses to HCV. The volume also includes contributions that explain the state of the art in IFN-alpha treatment of HCV patients.

 

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Contents

1 Innate Immunity in Type C Hepatitis
1
Lessons Learned from Cell Culture Studies
16
3 Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus
39
4 Immune Responses Against the Hepatitis C Virus and the Outcome of Therapy
71
Their Effects on Interferon141Ribavirin Treatment
87
6 InterferonInduced Effector Proteins and Hepatitis C Virus Replication
106
7 Treatment of Chronic Hepatitis C with Different Genotypes
130
From Basic Biology to Clinical Application
148
9 InterferonBased Therapy for Hepatitis C Virus Infections
168
10 Treatment of Chronic Hepatitis C in DifficulttoTreat Patients in the Clinical Setting
192
11 Effects of Combined IFNAlphaRibavirin Treatment in HCV DiseaseRelated Progression
215
Clinical Applications in the Management of Hepatitis C Infection
237
Subject Index
297
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Page 290 - Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised triaL Lancet 2001; 358:958-965.

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