Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies

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Elsevier Health Sciences, 2008 - Health & Fitness - 932 pages
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Presenting detailed, evidence-based coverage of the most commonly encountered therapeutic agents in modern clinical practice, this resource is designed to help you safely and effectively integrate herbal, nutrient, and drug therapy for your patients or clients. Combining pharmaceuticals with herbs or supplements may complement or interfere with a drug's therapeutic action or may increase adverse effects. Additionally, drug-induced depletion of nutrients can occur. Comprehensive clinical data, quick-reference features, and the insight and expertise of trusted authorities help you gain a confident understanding of how herbal remedies and nutritional supplements interact with pharmaceuticals and develop safe, individualized treatment strategies for your patients.

  • More than 60 comprehensive monographs of herb-drug and nutrient-drug interactions cover the most commonly used herbs and nutrients in health-related practice and help you coordinate safe, reliable therapy.
  • Each herb and nutrient monograph features summary tables and concise, practical suggestions that provide quick and easy reference and complement the systematic review and in-depth analysis.
  • References included on the bound-in CD provide high-quality, evidence-based support.
  • Unique icons throughout the text differentiate interactions, evidence, and clinical significance.
  • Up-to-date information keeps you current with the latest developments in pharmacology, nutrition, phytotherapy, biochemistry, genomics, oncology, hematology, naturopathic medicine, Chinese medicine, and other fields.
  • A diverse team of authoritative experts lends valuable, trans-disciplinary insight.
 

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LE Magazine April 2009 p 26
New Book Provides Definitive Guide to Supplement-Drug Interactions
The recent release of the landmark textbook Herb, Nutrient, and Drug Interactions: Clinical
Implications and Therapeutic Strategies provides the most detailed, complete source of information available on how commonly used herbs and nutrients interact with medications. Using these therapies together can support or interfere with a drug's action, or lead to adverse effects.
The book is co-authored by a team of practicing health care professionals with special expertise in integrative medicine: Dr. Mitchell Stargrove, a naturopathic physician, Jonathan Treasure, an authority on medical herbalism, and Dr. Dwight L. McKee, a diplomat of the boards of Internal Medicine, Medical Oncology, and Hematology. Over 60 of the most commonly used herbs and nutrients are covered in depth.
This collaborative effort goes beyond previous books on herb-drug-nutrient interactions in that it analyzes the source, strength, and relevance of the scientific studies, and clearly presents the information in a clinically relevant format. Special consideration is also given to how nutrients are depleted from the body by specific medications.
For instance, the book discusses 26 different classes of drugs that may interact with the essential B vitamin, folic acid. The common antidiabetic drug metformin (Glucophage®), for example, reportedly depletes folic acid by affecting its absorption. This may partially explain why higher homocysteine levels are seen with long-term metformin use. Folic acid and other B vitamins help keep homocysteine levels down. Since both diabetes and high homocysteine levels are associated with increased cardiovascular risk, folic acid supplementation appears to be especially crucial for metformin users.
Folic acid may also benefit individuals who use the cardiovascular drug nitroglycerin by preventing drug tolerance (decreased efficacy with use). Nitroglycerin becomes less effective at over time by interfering with the enzymes that make nitric oxide (NO), which is needed for healthy arterial function and blood flow. Co-administering folic acid with nitroglycerin may help enhance the drug's therapeutic effects.
Folic acid may also play an important role for those taking lithium or selective serotonin-reuptake inhibitor (SSRI) medications such as fluoxetine (Prozac®) for depression. Clinical studies have shown that folic acid supplementation enhances the antidepressant action of these pharmaceuticals, likely due to its role as a cofactor in the production of neurotransmitters, which control mood.
Drug therapy may be detrimental to vitamin K levels, which can be depleted by several classes of medications. Oral corticosteroids such as prednisone, for example, can cause increased urinary loss of vitamin K. Vitamin K deficiency contributes to vascular calcification as well as bone loss.
Coenzyme Q10 (CoQ10) is another important nutrient depleted by numerous common medicines, including sulfonylureas and related oral hypoglycemic agents for diabetes, tricyclic antidepressants, cholesterol-lowering statins, and the chemotherapy agent doxorubicin (Adriamycin®). Individuals using these drugs may thus benefit from CoQ10 supplementation.
The authors examine the possible interaction of CoQ10 with the anti-coagulant warfarin and find that it lacks clear scientific support. While four case reports have documented that CoQ10 interfered with the action of warfarin, existing studies are merely suggestive and fragmentary. Still, individuals who use warfarin should have their international normalized ratio (INR) levels closely monitored if they choose to supplement with CoQ10.
Access to accurate, clinically relevant information on herb-drug and nutrient-drug interactions is vital to anyone combining these therapies. Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies provides consumers with the ability to work with their doctors to confidently design safe and effective
 

Contents

HERBDRUG INTERACTIONS Aloe
1
Astragalus
5
Bilberry
9
Black Cohosh
12
Cascara
17
Cayenne
20
Dang Gui
26
Devils Claw
30
Folic Acid
186
Vitamin A Retinol
235
Vitamin B1 Thiamine
253
Vitamin B2 Riboflavin
263
Vitamin B3 Niacin
281
Vitamin B6
306
Vitamin B12
338
Ascorbic Acid
356

Echinacea
32
Eleuthero
39
Ephedra
42
Feverfew
49
Garlic
53
Ginger
62
Ginkgo
69
Ginseng
80
Nutraceuticals and Physiologics
87
Gotu Kola
88
Green Tea
91
Hawthorn
99
Horse Chestnut
104
Kava
106
Licorice
113
Milk Thistle
123
Red Clover
131
Reishi
133
Saw Palmetto
137
St Johns Wort
140
TurmericCurcumin
160
Valerian
167
Vitex
171
A Vitamins BetaCarotene
173
Calciferol
399
Vitamin E
422
Vitamin K
447
B Minerals Boron
458
Calcium
464
Chromium
499
Copper
511
Iron
522
Magnesium
556
Potassium
583
Selenium
609
Zinc
618
Amino Acids
620
Arginine
653
Carnitine
661
Methionine
677
Phenylalanine
682
Tryptophan
690
Tyrosine
698
5Hydroxytryptophan
706
CROSSINDEXES
832
INDEX
891
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