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Advances in technology to improve HTS developing multiplexed assays
Microfluidic devices a route to the integration of biology and chemistry
The potential of molecular biophotonics in drug discovery
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absorbance Acceptor beads acid active ALPHAScreen analysis animal models antibodies applications approach ArrayScan automated binding affinity biological targets bioluminescent Biophotonic bottleneck buffer c-Src Cathepsin cell line cell-based Cellomics cellular knowledge chemical libraries chemical synthesis chip combinatorial chemistry combinatorial libraries complexes concentration Contag cycle databases demonstrate detection disease docked energy drug discovery drug discovery process enzyme expression Figure FLISA fluorescence FMAT function gene genomics Glaxo Wellcome gradient Hamamatsu High Content Screening high throughput screening identified imaging in-vivo increase industry inhibition integrated ionizable kinase ligand luciferase lux operons measured methods mice microfluidic microreactors miniaturization molecular molecules monitor multiplexed assays natural products novel peptide performance pg/ml photons plate polyketide potential protein proteomics reaction reagents receptor sample selected serine proteases SGA technique signal specific structure substituent substrate Tabu search templates thrombin thrombin ligands transgenic vivo wavelengths Xenorhabdus