Hippocampal Microcircuits: A Computational Modeler's Resource Book

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Vassilis Cutsuridis, Bruce P. Graham, Stuart Cobb, Imre Vida
Springer Science & Business Media, Feb 1, 2010 - Medical - 617 pages
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The hippocampus is thought to play a role in the short-term storage of declarative memories in the human brain. Our understanding of its anatomy, physiology and molecular structure has expanded rapidly in recent years. Yet much still needs to be done to decipher the function of the detailed microcircuits. This overview of our current knowledge of the hippocampus also provides a snapshot of the state of the art of ongoing research into these microcircuits.

Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-cell and network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models.

In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.


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Connectivity of the Hippocampus
Morphology of Hippocampal Neurons
Physiological Properties of Hippocampal Neurons
Glutamatergic Neurotransmission in the Hippocampus
Fast and Slow GABAergic Transmission in Hippocampal Circuits
Synaptic Plasticity at Hippocampal Synapses
Neuromodulation of Hippocampal Cells and Circuits
Neuronal Activity Patterns During Hippocampal Network Oscillations In Vitro
Entorhinal Cortex Cells
Gamma and Theta Rhythms in Biophysical Models of Hippocampal Circuits
Associative Memory Models of Hippocampal Areas CA1 and CA3
Microcircuit Model of the Dentate Gyrus in Epilepsy
Multilevel Models
BiophysicsBased Models of LTPLTD
A Phenomenological CalciumBased Model of STDP

Neuronal Activity Patterns in Anaesthetized Animals
A Primer for Computational Analysis
The Making of a Detailed CA1 Pyramidal Neuron Model
Detailed and Simplified Pyramidal Cell Models
Computer Simulation Environments

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About the author (2010)

Dr. Vassilis Cutsuridis is a Research Fellow in the Department of Computing Science and Mathematics at the University of Stirling, Scotland, UK.
Bruce P. Graham is a Reader in Computing Science in the Department of Computing Science and Mathematics at the University of Stirling.
Stuart Cobb is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow, Scotland, UK.
Imre Vida is a Senior Lecturer in the Neuroscience and Molecular Pharmacology Department at the University of Glasgow.

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