Histopathology of Preclinical Toxicity Studies: Interpretation and Relevance in Drug Safety Evaluation

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Academic Press, 2012 - Medical - 886 pages
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The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

NEW TO THE FOURTH EDITION:

*This edition is in full color and features nearly 200 high-quality images

*Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading

*Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions.

 

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Contents

1 Introduction
1
2 Integumentary System
11
3 Mammary Gland
69
4 Hemopoietic and Lymphatic Systems
99
5 Musculoskeletal System
157
6 Respiratory Tract
207
7 Cardiovascular System
263
8 Digestive System
325
9 Liver and Pancreas
433
10 Urinary Tract
537
11 Male Genital Tract
615
12 Female Genital Tract
667
13 Endocrine Glands
725
14 Nervous System and Special Sense Organs
799
Index
867
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About the author (2012)

MBChB, FRCPath, Consulting Pathologist and Honorary Senior Lecturer, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK

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