History of the Synapse

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CRC Press, Sep 2, 2003 - Science - 350 pages
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The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a conceptual structure that would allow the synapse to be identified at the beginning of the 20th century. Numerous illustrations explain either the technical approach or the experimental finding.
 

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Contents

from Plato to Sherrington
1
2 Emergence of the Concept of Transmitter Release at Peripheral and Central Synapses
26
3 The Discovery of Acetylcholine and the Concept of Receptors at Synapses
43
4 The Discovery of Adrenaline and the Concept of Autoreceptors at Synapses
65
5 The Discovery of Amino Acid Transmission at Synapses in the Central Nervous System
77
the Discovery of Neuroleptics
90
7 The Discovery of Transmitters Other than Noradrenaline and Acetylcholine at Synapses in the Peripheral Nervous System
105
8 Development of the Concept of a Calcium Sensor in Transmitter Release at Synapses
136
10 The Discovery of Longterm Potentiation of Transmission at Synapses
216
11 Emergence of the Concept of Synapse Formation Molecules
238
Epilogue
286
References
288
Illustration Acknowledgements
328
Acknowledgements
332
Index
334
Copyright

9 The Discovery of Quantal Secretion and the Statistics of Transmitter Release at Synapses
164

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