History of the Synapse
The History of the Synapse provides a history of those discoveries concerning the identification and function of synapses that provide the foundations for research during this new century with a personal view of the process by which new concepts have developed. Previously published as essays, the chapters in this book provide a history of various aspects of synaptic function, beginning with the evolution over two and a half thousand years and how progress was made in the establishment of a conceptual structure that would allow the synapse to be identified at the beginning of the 20th century. Numerous illustrations explain either the technical approach or the experimental finding.
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from Plato to Sherrington
2 Emergence of the Concept of Transmitter Release at Peripheral and Central Synapses
3 The Discovery of Acetylcholine and the Concept of Receptors at Synapses
4 The Discovery of Adrenaline and the Concept of Autoreceptors at Synapses
5 The Discovery of Amino Acid Transmission at Synapses in the Central Nervous System
the Discovery of Neuroleptics
7 The Discovery of Transmitters Other than Noradrenaline and Acetylcholine at Synapses in the Peripheral Nervous System
8 Development of the Concept of a Calcium Sensor in Transmitter Release at Synapses
9 The Discovery of Quantal Secretion and the Statistics of Transmitter Release at Synapses
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acetylcholine AChR action potential active zone adrenaline adrenergic adrenoceptor agrin alpha amino acids amplitude antagonists atropine autonomic axons basal lamina Bennett binomial blocked brain Burnstock calcium channels calcium concentration calcium ions clozapine collaterals contraction Dale denervated depolarisation discovery distribution Eccles effects electrical electrode endplate potential excitatory experiments frog GABA ganglia gastrointestinal tract glutamate guinea-pig hippocampus histogram impulse increase indicated inhibition intestine intracellular junction potentials Katz Langley loss of polyneuronal mediated membrane Miledi molecules motoneurones motor units muscle cells muscle fibres myotubes NANC nerve stimulation nerve terminals nervous system neuroleptics neuromuscular junction neurones Neurosci NMDA noradrenaline normal observed parameters Pharmacol Physiol polyneuronal innervation postsynaptic presynaptic protein quantal quantal release recorded reinnervation response Sherrington showed shown smooth muscle sodium soleus soleus muscle spinal cord substance subunit sympathetic nerve synapse formation synaptic sites synaptic terminals synaptotagmin taenia coli tetrodotoxin transmitter release vagal