Homocysteine in Health and Disease

Front Cover
Ralph Carmel, Donald W. Jacobsen
Cambridge University Press, Jul 19, 2001 - Medical - 510 pages
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High levels of homocysteine, a sulfur-containing amino acid derived from methionine, have recently been identified as a very important risk factor in cardiovascular disease. Homocysteine abnormalities are also thought to contribute to birth defects and dementia. There are many common genetic disorders and problems (such as vitamin deficiency) that adversely affect the metabolism of homocysteine. In this book a team of the world's experts in the field provide a clear, current, clinical analysis of the biochemistry, genetics, and epidemiology of homocysteine disorders, providing a uniquely comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine for health and disease.
 

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Contents

Historical overview and recent perspectives
xvii
Practical Chemistry of Homocysteine and Other Thiols
7
Biosynthesis and reactions of homocysteine thiolactone
19
Unique aspects of sulfur chemistry Homocysteine and lipid oxidation
30
Homocysteine nitric oxide and nitrosothiols
37
Section Two Biochemistry and Metabolism
45
SAdenosylmethioninedependent Methyltransferases
61
SAdenosylhomocysteine hydrolase
77
Polymorphisms of Folate and Cobalamin Metabolism
255
Folate Deficiency
267
Cobalamin Deficiency
285
Vitamin B6 Deficiency
303
Homocysteine in Renal Disease
317
Diseases and Drugs Associated with Hyperhomocysteinemia
327
Lifestyle Factors Associated with Hyperhomocysteinemia
337
Clinical Consequences in Hyperhomocysteinemia
353

Regulation of Homocysteine Metabolism
90
Microbial Modeling of human disease Homocysteine metabolism
98
Folate Metabolism
111
Cobalamindependent remethylation
133
Betainedependent remethylation
143
The Transsulfuration Pathway
151
Transport and Tissue Distribution of Homocysteine and Related SAdenosyl Compounds
159
Homocysteine and the Kidney
172
Homocysteine and the Nervous System
179
Methodologies of Testing
195
Methionine Loading
208
Cystathionine Synthase and Its Deficiency
219
Inborn Errors of Folate and Cobalamin Metabolism
240
Homocysteine and coronary artery disease
367
Homocysteine and cerebral vascular disease
380
Peripheral arterial disease
389
Venous disease
397
Homocysteine and Hemostasis
411
Cellular mechanisms of homocysteine pathogenesis in atherosclerosis
421
Homocysteine and cardiovascular physiology
437
Homocysteine and human reproduction TKAB Eskes
447
Intervention and Therapy
463
Design of clinical Trials to test the homocysteine hypothesis of vascular disease
473
What is a desirable homocysteine Level?
481
Index
487
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