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Acknowledgment Frank H Clarke
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absorption acid action addition agents analgetic animal anti-TB activity anti-TB drugs approach bioavailability biological blood level capsules cell chemical development chemical engineer CIBA-GEIGY clini clinical evaluation clinical studies Company components compound cortisone cost cyclazocine development chemist developmental research discovery disease dissolution rate dissolution test dosage form doses drug development drug product design drug release efficacy enzyme equipment ethambutol excretion final formulation glandins gram hormone human Hydroxybutylethylenediamine imipramine INDOMETHACIN infected investigators involved isoniazid laboratory Lederle lysozyme manufacturing ment metabolism mice molecules morphine nalorphine naloxone naltrexone narcotic antagonist operating package patients peptide PGE2 PGF2-alpha pharmaceutical industry pharmaceutical research pharmacological Pharmacy phenylbutazone pilot plant potential product development prostaglandins protovirus quality control raw materials reaction research and development safety Sample scientific scientists screening side effects solution specific structure substance sulfinpyrazone synthesis synthetic tablet TB bacillus therapeutic therapy tion toxicity tuberculosis Upjohn uricosuric York