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absorption acetylcholine action potential activity administration adrenergic agents agonists amino acid aminoglycosides androgen anesthetic antagonists antibiotics bacteria benzodiazepines binding block blockers blood pressure brain Ca++ calcium cardiac cause cells cellular centrations cephalosporins channels Chapter cholesterol cholinergic CLINICAL PROBLEMS compounds creased decrease depolarization depression disease diuretics dopamine dose drug enzyme epinephrine estrogen ethanol excreted factors Figure fluid function glucocorticoids glycosides half-life heart hepatic histamine hormone hypertension increase infections inhibition inhibitors insulin interactions intestinal intracellular kinase lipid liver MECHANISMS OF ACTION membrane metabolism metabolites muscarinic nerve terminal nervous system neurons neurotransmitter norepinephrine normal occur opioid Oral organisms oxide pathways patients penicillin peptide peripheral Pharmacokinetic pharmacological plasma concentrations produce prostaglandins protein receptors reduce release renal resistance response result secretion serum side effects smooth muscle sodium specific stimulation structures sympathetic synaptic synthesis THERAPEUTIC OVERVIEW therapy tion tissue toxicity tract transmitter treat treatment tumor types urine vascular vasodilation vitamin