Human Pharmacology: Molecular to Clinical, Volume 918
Theodore M. Brody, Joseph Larner, Kenneth P. Minneman
Mosby, 1998 - Medical - 1001 pages
Unique among pharmacology textbooks, HUMAN PHARMACOLOGY: MOLECULAR TO CLINICAL organizes drugs of a class according to the characteristics of the class, with individual drugs discussed in relation to other drugs of the class. This approach helps students understand strengths and weaknesses of drugs, both in comparison with each other and in certain clinical conditions. The standard format allows for quick reference, and the more than 400 full-color illustrations focus on processes and mechanisms.
Material is current, with changes reflecting today's pharmacotherapy. Unique New Horizons section discusses drugs being evaluated by the FDA for use in the next two to three years. Hundreds of color-coded boxes and tables allow for rapid access, and summary tables are now more "crammable." Superb index gives user quick access to specific information. Hundreds of excellent color illustrations describe important processes, structures, and interactions. USMLE-type questions at the ends of chapters allow for on-going self-assessment.
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10 Drugs Affecting the Sympathetic Nervous
ConcentrationResponse Relationships 27 13 5Hydroxytryptamine Serotonin
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acetylcholine action potential activity administered adrenal adrenergic adrenergic receptors agents agonists androgen anesthetic antagonists benzodiazepines binding block blockade blockers blood pressure brain Ca2+ calcium cardiac cause ceptors channels Chapter cholesterol choline cholinergic cholinesterase clearance compounds concentration of drug crease cyclase decrease depolarization disease diuretics dopamine dose enzyme epinephrine estrogen ethanol excretion factors Figure function gene therapy gene transfer glucocorticoids glycosides half-life heart hepatic hormone hypertension increase inhibit inhibitors insulin interactions intracellular kinase ligand lipid liver MECHANISMS OF ACTION metabolism metabolites molecular molecules muscarinic nerve terminals nervous system neuromuscular neurons neurotransmitter nicotinic norepinephrine normal occur opioid oral parasympathetic pathway patients peripheral pharmacokinetic pharmacological plasma concentration platelet produce Propranolol prostaglandins protein receptors reduced release renal response result retrovirus secretion side effects smooth muscle sodium specific stimulation subtypes subunit succinylcholine sympathetic synaptic synthesis target testosterone THERAPEUTIC OVERVIEW tion tissue toxicity transmitter transport treatment vascular vivo