Huntington's disease is a genetically inherited condition which results in severe nerve-cell damage in the brain. The hereditary and debilitative nature of the disease means that many people are involved either directly or indirectly by this condition. The recent identification of the faulty gene involved has made the diagnosis of this condition simpler. The majority of people develop the disease between the ages of 35 and 55 years, so for those aware of their genetic risk there are dilemmas to consider - should you have a test to see if you have the gene? Should you start a family? The new edition of this successful book specifically designed for families of patients with Huntington's disease has been expanded to include a number of important new developments in research and clinical practice that have occurred in the field in recent years. While there are no drugs currently available that slow down or reverse the neurodegenerative process in Huntington's Disease, there is growing data on the use of existing treatments to manage movement disorder, irritability and depression associated with the condition, which are covered here. This edition also includes completely new chapters covering juvenile Huntington's disease and late-stage Huntington's disease, and a fully updated Appendix of relevant patients' organizations.
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2 The physical features of Huntingtons disease
3 Behavioural and emotional aspects of Huntingtons disease
4 Juvenile Huntingtons disease
5 The genetics of Huntingtons disease
6 Laboratory testing
a new diagnosis in the family
8 Genetic counselling for unaffected family members
9 Changes in the brain
Other editions - View all
50 per cent abnormal huntingtin affected age of onset aggregates assess basal ganglia bradykinesia brain building blocks CAG repeats carer caudate and putamen caudate/putamen cell death cent risk changes Chapter chemical chorea chromosome copy cortex depression described develop Huntington’s disease develop the condition Diagram difficult discuss DNA molecule doctor drugs dystonia Email family members features of Huntington’s gene for Huntington’s genetic counselling genetic counsellor genetic material genetic test globus pallidus glutamine huntingtin protein Huntington’s chorea Huntington’s disease gene indirect pathway individual involved juvenile Huntington’s disease laboratory marker medium spiny neurons movement disorder mutation nerve cell nerve cell damage neurological normal number of different occur option parent patients with Huntington’s person with Huntington’s possible predictive test putamen receptors result risk of Huntington’s someone with Huntington’s sperm stages subthalamus thalamus thefacts treatment ubiquitin unaffected Website X chromosome