Imaginal Discs: The Genetic and Cellular Logic of Pattern Formation

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Cambridge University Press, Aug 22, 2005 - Science - 480 pages
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Many of the 14,000 genes of Drosophila are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully-functioning fly. This book examines the genetic circuitry of the well-known 'fruit fly', tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogues of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. No student or practising scientist engaged in the study of Drosophila genetics should be without this comprehensive reference.
 

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Contents

CHAPTER ONE CELL LINEAGE VS INTERCELLULAR SIGNALING
1
CHAPTER TWO THE BRISTLE
5
CHAPTER THREE BRISTLE PATTERNS
31
CHAPTER FOUR ORIGIN AND GROWTHOF DISCS
76
CHAPTER FIVE THE LEG DISC
97
CHAPTER SIX THE WING DISC
137
CHAPTER SEVEN THE EYE DISC
197
CHAPTER EIGHT HOMEOSIS
237
APPENDIX TWO Inventory of Models Mysteries Devices and Epiphanies
266
APPENDIX THREE Genes That Can Alter Cell Fates Within the 5Cell Mechanosensory Bristle Organ ...
271
APPENDIX FOUR Genes That Can Transform One Type of Bristle Into Another or Into a Different Type of Sense Organ ...
276
APPENDIX FIVE Genes That Can Alter Bristle Number by Directly Affecting SOP Equivalence Groups or Inhibitory Fields ...
278
Hedgehog Decapentaplegic and Wingless
285
APPENDIX SEVEN Commentaries on the Pithier Figures
297
References
307
Index
441

EPILOGUE
256
APPENDIX ONE Glossary of Protein Domains
257

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