Imaginal Discs: The Genetic and Cellular Logic of Pattern Formation
Many of the 14,000 genes of Drosophila are involved in the development of imaginal discs. These hollow sacs of cells make adult structures during metamorphosis, and their study is crucial to comprehending how a larva becomes a fully-functioning fly. This book examines the genetic circuitry of the well-known 'fruit fly', tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the book delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogues of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. No student or practising scientist engaged in the study of Drosophila genetics should be without this comprehensive reference.
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CHAPTER ONE CELL LINEAGE VS INTERCELLULAR SIGNALING
CHAPTER TWO THE BRISTLE
CHAPTER THREE BRISTLE PATTERNS
CHAPTER FOUR ORIGIN AND GROWTHOF DISCS
CHAPTER FIVE THE LEG DISC
CHAPTER SIX THE WING DISC
CHAPTER SEVEN THE EYE DISC
CHAPTER EIGHT HOMEOSIS
APPENDIX TWO Inventory of Models Mysteries Devices and Epiphanies
APPENDIX THREE Genes That Can Alter Cell Fates Within the 5Cell Mechanosensory Bristle Organ ...
APPENDIX FOUR Genes That Can Transform One Type of Bristle Into Another or Into a Different Type of Sense Organ ...
APPENDIX FIVE Genes That Can Alter Bristle Number by Directly Affecting SOP Equivalence Groups or Inhibitory Fields ...
Hedgehog Decapentaplegic and Wingless
APPENDIX SEVEN Commentaries on the Pithier Figures
APPENDIX ONE Glossary of Protein Domains
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Abstracts Vol Acad activation alleles antenna arise AS-C bHLH binding BioEssays Biol boundary bristles cell fate clones compartment complex cone cells Curr decapentaplegic Development 124 Developmental differentiation diffusion dimers distal domain dorsal Dpp and Wg dpp-on Drosophila embryo Drosophila eye Drosophila melanogaster Drosophila wing ectopic Egfr encodes engrailed enhancer eye disc flies function gene expression Genes Dev gradient Hairy Hedgehog homeobox homeosis homeotic genes imaginal discs induced inhibition inhibitor instar interactions Iro-C kinase leg disc ligand lineage Mechs Model Molecular morphogen morphogenesis motif mutations neurons Notch pathway Notch signaling notum Numb ommatidia overexpressed phenotype photoreceptor polarity prepattern Proc proneural protein receptor region regulation role scute segment sex comb socket stripe Su(H target genes tion tissue transcription factors transduction Trends Genet vein ventral wild-type wing disc Wingless