Imidazole and Benzimidazole Synthesis
Imidazole and Benzimidazole Synthesis is a comprehensive survey of the known methods of syntheses and ring modification. It brings together the multitude of synthesis of the imidazole ring in a systemic way interms of specific bond formation, and recommends the most attractive synthetic approaches. It also collects non-ring-synthetic approaches to classes of compounds such as nitro-, halogeno-, and amino-imidazoles, and covers the synthesis of N-substituted compounds and preparations of specific isomers.
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1-substituted 20 mmol A. R. Katritzky Abstr acetic acid acetonitrile acyl added dropwise aldehyde alkyl amidine amino ammonia aqueous aryl benzene benzimidazole bromide carbon carboxylic catalytic CH2Ph Chem Chim chloride chloroform chromatography CO2Et compounds converted cooled cyclization derivatives dichloromethane diethyl ether dissolved distilled dried MgSO4 dried Na2SO4 electrophilic ester ethanol ethyl acetate extracts are dried filtered filtrate formamidine formed give the product Heterocycl hexane high yields hydrochloride hydrogen imidate imidazoles M. R. Grimmett method mixture is stirred mmol n-butyllithium N-oxides nitrile nitrogen nucleophilic o-phenylenediamine oxidation Perkin Trans potassium precipitate presence react reaction mixture readily reagent recrystallized reduced pressure residue ring room temperature rotary evaporated salts Scheme Section silica gel Similarly prepared sodium hydroxide solid stirred at room stirred solution substituted substrates synthesis synthetic Tetrahedron Lett TOSMIC Transl triethylamine USSR Engl washed with water yield given
Page ii - WB Motherwell and D. Crich, Free Radical Chain Reactions in Organic Synthesis, 1991 N. Petragnani, Tellurium in Organic Synthesis, 1994 T. Imamoto, Lanthanides in Organic Synthesis, 1994 AJ Pearson, Iron Compounds in Organic Synthesis, 1994 P. Metzner and A. Thuillier, Sulfur Reagents in Organic Synthesis, 1994 B.