Immobilized enzymes in medicine
Springer-Verlag Berlin And Heidelberg Gmbh & Company K, 1991 - Immobilized enzymes - 206 pages
The application of immobilized enzymes in medicine is the main objective of this book. The author reviews natural and synthetic carriers for enzyme immobilization, chemistry of enzyme binding, and in-vitro and in-vivo properties of immobilized enzymes. Four chapters are dedicated to clinical use of immobilized enzymes.
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Immobilization of Therapeutic Enzymes
Therapeutic Immobilized Enzymes for Parenteral Application
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administration albumin ammonia antibodies antigen application asparaginase asparagine Biochem Biochim Biophys Acta biodegradable biological blood flow catalase cell ghosts Chang TMS Chem chemical cholesterol circulation clinical compounds conjugates containing cross-linked decrease dehydrogenase dextran diseases drug effect encapsulated entrapped enzymatic enzyme activity enzyme electrodes enzyme immobilization enzyme stabilization enzyme therapy erythrocytes experimental extracorporeal fibers fibrin glucocerebrosidase glucose oxidase Gregoriadis groups half-life heparin immobilized enzymes inactivation incorporation increase inhibitor injection interaction intravenous liposomes liver luciferase lysis lysosomal magnetic membrane methods mice microcapsules modified molecular weight molecules native enzyme obtained organism peroxidase phenylalanine physiological plasmin plasminogen activator Polyethylene glycol polymeric polymeric carrier polymers preparations properties protein proteolytic enzymes reaction reactor reagent red blood cells release Reproduced with permission Russ Smirnov VN soluble polymers solution specific streptokinase substrates surface target therapeutic enzymes thrombolytic thrombolytic enzymes thrombus tissue Torchilin VP toxic treatment trypsin tumor urea urease uricase urokinase vitro vivo