Immunity to Parasites: How Parasitic Infections are Controlled
This completely updated second edition provides a clear account of how immune responses operate and how parasites can evade immunity. Parasites have evolved to exploit hosts' bodies, whereas hosts have evolved immune systems to control infections. Host-parasite interactions therefore provide fascinating examples of evolutionary "arms-races" in which the immune system plays a key role. Including an expanded section on anti-parasite vaccines, the text focuses on modern research in immunoparasitology directed at understanding and exploiting the capacity to develop effective anti-parasite immunity. The experimental basis of this research is emphasized throughout. The text is aimed at undergraduates and postgraduates with interests in either parasitology or immunology and contains introductory sections on these topics.
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Parasites and parasitism
The immune response
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activity ADCC adult worms animals anti anti-parasite antibody antigen presentation antigenic variation associated BALB/c basophils binding blood complement complex components cycle cytokines cytotoxic disease effective enzymes eosinophils epitopes experimental expressed factors falciparum feeding filarial function genes genetically glycoprotein helper cells host cell humans hypersensitivity IFN-Y immune responses immunogenic immunoglobulin immunological important infective stages inflammatory initial interaction intestine intracellular involved irradiated isotype larvae Leishmania levels liver lymphocytes macrophages major malaria mansoni mast cells mediators membrane merozoite mice microfilaria molecules mouse mucosa nematodes normal occur parasitaemia parasite parasite antigens Parasitology pathology peptides phagocytosis plasma Plasmodium populations production protective immunity protective responses proteins Protozoa rats receptors recombinant reinfection release resistance role schistosomes schistosomula sequences serum skin species sporozoite stichosomal strains studies subset surface antigens survival susceptible target tegument ticks tion tissues Trichinella trypanosomes vaccine variety vector vitro worm expulsion