Immunologic Signatures of Rejection
Francesco M. Marincola, Ena Wang
Springer Science & Business Media, Nov 3, 2010 - Medical - 353 pages
This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity).
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Acad Sci U S A activation acute rejection allograft analysis angiogenesis antibody antigen antitumor associated autoimmune Biol biomarkers biopsies cancer patients Cancer Res carcinoma CCR5 CD4+ CD8+ T cells cell responses cellular CGVHD chemokine receptor chronic Clin clinical CXCL9 CXCR3 cytokines cytotoxic dendritic cells donor effector endothelial Foxp3 function gene expression profiling Genomics graft graft-versus-host disease granzyme HAM/TSP human IFN-g immune cells immune system Immunol immunological immunotherapy induced infection infiltration inflammation inflammatory inhibition innate immune interferon kidney ligands liver lymphocytes macrophages Mantovani Marincola mechanisms mediated melanoma metastatic mice microarray molecular molecules Natl Acad Sci neutrophils NF-kB NK cells ovarian cancer pathways peripheral blood phenotype Proc Natl Acad production protein regulation regulatory T cells renal role Sarwal signaling signatures STAT3 studies subsets T-cell Th17 cells therapy tissue Toll-like receptor transcription factor transplant Treg cells tumor tumor cells tumor microenvironment tumor rejection upregulated vaccine viral vivo Wang Zhang