Immunology of Behçet's Disease

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CRC Press, Jul 3, 2013 - Medical - 186 pages
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Behçet's Disease (BD) is one of the most-studied systemic disorders characterized by an occlusive vasculopathy of multiple organs. The etiology and pathogenesis of BD are still unclear, but there is evidence for genetic, immunologic and infectious factors in the onset and throughout the course of the disease. Immunology of Behçet's Disease highlights various aspects of BD. After an epidemiological overview, the clinical presentation of ocular and non-ocular symptoms of BD are summarized. The immunopathological changes reflect a chronic vasculitis of arterioles, venules and capillaries. The role of T-cells, but also of NK-T-cells, secreted cytokines and neutrophils is covered. For years microorganisms have been under investigation as initiating BD and, in particular, immune reactions against various microbial heat shock proteins could be an important etiological factor. It has been shown that the pathogenic gene involved in the development of BD is pinpointed to HLA-B51. Finally, the treatment of BD is discussed in detail, including new options like anti-TNF-alpha-antibodies and interferon-alpha. Immunology of Behçet's Disease summarizes our knowledge regarding the most important factors that induce or trigger BD and will stimulate research in the field and help to initiate new ideas.
 

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Contents

1 Epidemiology of AdamantiadesBehçets Disease
1
2 A Proposal to Study the Frequency of Rare Diseases
17
3 NonOcular Manifestations
21
4 Ocular Manifestations in Behçets Disease
37
5 Immunohistopathology of Behçets Disease
47
6 T Cells in Behçets Disease
57
7 NK and NKT Cells Possibly Involved in Behçets Disease
63
8 Cytokines in Behçets Disease
73
13 The Role of Heat Shock Proteins in Behçets Disease
113
14 Association of HLAB51 Suballeles with Behçets Disease in Patients of German and Turkish Origin
121
15 Peptide Motif of HLAB5101 and the Linkage To Behçets Disease
127
16 Microsatellite Mapping of the Pathogenic Gene of Behçets Disease
139
17 The Treatment of Behçet
145
18 The Efficacy of AntiTNFAlpha Antibody in the Treatment of Uveitis Patients with Behçets Disease
151
19 Use of Interferonaa in Behçets Disease
155
20 Type I Interferon Treatment of Experimental Autoimmune Uveoretinitis
161

9 Autoimmunity in Behçets Disease
81
10 An Attempt To Create A Behçets Disease Model In Mice
87
11 Neutrophil Hyperfunction in Behçets Disease
97
12 Role of Infectious Organisms in Behçets Disease
103
Authors
167
Index
173
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