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Immunology of hematopoietic stem
RE Mebius S J Morrison J Shizuru S Strober N Uchida biology and transplantation
B R Blazar R Korngold D A Vallera Recent advances in graftversushost disease GVHD
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Acad Sci USA activity adoptive transfer alleles allogeneic allogeneic bone marrow allograft antigen-specific antitumor assay autologous autoreactive bone marrow transplantation CD4+ T cells CD8+ cellular chronic clinical clones CTLp cultured T cells cytokines cytotoxic T cells donor T cells dose EBV LPDs EBV-specific effect engraftment epitopes Epstein-Barr virus expression function gene graft-versus-host disease GVHD hematopoietic stem cells HLA-A HLA-identical host HSCs human Immunol Immunological immunotherapy induced infection infusion inhibit interleukin irradiated lethal leukemia leukemic ligand lymphocytes lymphoid lymphoma marrow grafts mediated mHag MHC class mice minor histocompatibility antigens mismatches molecules mouse murine myeloid Nat l Acad natural killer cells NK cells patients peptide peripheral blood phenotype populations post-BMT Proc Nat progenitors proliferation protein receptor recipients reconstitution relapse specific spleen studies subsets survival syngeneic syngeneic GVHD T-cell depletion target therapy thymic thymocytes thymus tion treatment tumor unrelated donor vitro vivo