Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

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Darren R. Flower, Yvonne Perrie
Springer Science & Business Media, Dec 9, 2012 - Medical - 314 pages
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This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
 

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Contents

Chapter 1 Immunomic Discovery of Adjuvants Delivery Systems and Candidate Subunit Vaccines A Brief Introduction
1
Chapter 2 Bacterial Genomes and Vaccine Design
13
Chapter 3 Identification of Candidate Vaccine Antigens In Silico
38
Chapter 4 Postgenomic Antigen Discovery Bioinformatical Approaches to Reveal Novel T Cell Antigens of Mycobacterium bovis
73
Chapter 5 GenomeBased Computational Vaccine Discovery by Reverse Vaccinology
91
Chapter 6 Computational Prediction of Protein Subcellular Localization Genomic Islands and Virulence to Aid Antigen Discovery
105
Chapter 7 On the Development of Vaccine Antigen Databases Progress Opportunity and Challenge
116
Chapter 8 What Have Dendritic Cells Ever Done for Adjuvant Design? Cellular and Molecular Methods for the Rational Development of Vaccine Ad...
131
Chapter 10 Designing Liposomes as Vaccine Adjuvants
181
Chapter 11 Designing Nonionic Surfactant Vesicles for the Delivery of Antigens for Systemic and Alternative Delivery Routes
205
Chapter 12 Immune Stimulating Complexes ISCOMs and QuilA Containing Particulate Formulations as Vaccine Delivery Systems
233
Chapter 13 Formulation and Characterisation of PLGA Microspheres as Vaccine Adjuvants
262
Chapter 14 Powder Vaccines for Pulmonary Delivery
291
About the Author
302
Index
305
Copyright

Chapter 9 Towards the Systematic Discovery of Immunomodulatory Adjuvants
155

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About the author (2012)

Dr. Darren R Flower. An interdisciplinary scientist, with special interest in bioinformatics, computational chemistry, and cheminformatics, Dr. Flower has wide-ranging experience of the pre-clinical research environment in both academia and the pharmaceutical industry. Before joining Aston University as a Reader, Dr. Flower was a Jenner Research Fellow and Principal Investigator at the University of Oxford; and formerly a Senior Group Leader managing a large research group at The Edward Jenner Institute for Vaccine Research. Before that, Dr. Flower was a drug discovery scientist in the Pharmaceutical industry. Dr. Flower is a Fellow of the Royal Society of Chemistry, and the author of over 150 research papers and reviews, and 7 Books, including the monograph: Bioinformatics for Vaccinology.

Professor Yvonne Perrie is Pharmacist whose research focuses on the development on delivery systems for drugs and vaccines. Prof. Perrie is currently Head of Pharmacy and Chair in Drug Delivery within Aston University. Prof. Perrie received her Ph.D. from the University of London, UK where she investigated the use of liposomes for gene delivery under the supervision of Professor Gregory Gregoriadis. Prof. Perrie then joined a newly established Drug Delivery Company, Lipoxen Technologies Ltd., prior to taking her post at Aston University. Prof. Perrie is currently Chair of the UK and Ireland Controlled Release Society and has approximately 100 research papers and reviews focusing on the research and development of drug delivery systems.

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