Immunomic Discovery of Adjuvants and Candidate Subunit VaccinesDarren R. Flower, Yvonne Perrie This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants. |
Contents
| 1 | |
Chapter 2 Bacterial Genomes and Vaccine Design | 13 |
Chapter 3 Identification of Candidate Vaccine Antigens In Silico | 38 |
Chapter 4 Postgenomic Antigen Discovery Bioinformatical Approaches to Reveal Novel T Cell Antigens of Mycobacterium bovis | 73 |
Chapter 5 GenomeBased Computational Vaccine Discovery by Reverse Vaccinology | 91 |
Chapter 6 Computational Prediction of Protein Subcellular Localization Genomic Islands and Virulence to Aid Antigen Discovery | 105 |
Chapter 7 On the Development of Vaccine Antigen Databases Progress Opportunity and Challenge | 116 |
Chapter 8 What Have Dendritic Cells Ever Done for Adjuvant Design? Cellular and Molecular Methods for the Rational Development of Vaccine Ad... | 131 |
Chapter 10 Designing Liposomes as Vaccine Adjuvants | 181 |
Chapter 11 Designing Nonionic Surfactant Vesicles for the Delivery of Antigens for Systemic and Alternative Delivery Routes | 205 |
Chapter 12 Immune Stimulating Complexes ISCOMs and QuilA Containing Particulate Formulations as Vaccine Delivery Systems | 233 |
Chapter 13 Formulation and Characterisation of PLGA Microspheres as Vaccine Adjuvants | 263 |
Chapter 14 Powder Vaccines for Pulmonary Delivery | 291 |
About the Author | 302 |
| 305 | |
Chapter 9 Towards the Systematic Discovery of Immunomodulatory Adjuvants | 155 |
Other editions - View all
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Darren R. Flower,Yvonne Perrie No preview available - 2015 |
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Darren R. Flower,Yvonne Perrie No preview available - 2012 |
Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Darren R. Flower,Yvonne Perrie No preview available - 2012 |
Common terms and phrases
adjuvant activity agonists analysis antibody antigen approach bacterial bilayer binding Bioinformatics bovis cationic cellular cholesterol clinical complex components cytokines database DC activation delivery systems dendritic cells discovery disease drug effective enhance epitopes Flower DR formulation genes genome sequence genomic islands host human identified immune responses immune system immunogenicity immunoinformatics Immunol immunology induce infection inflammasome influenza Int J Pharm interactions ISCOM matrix lipid liposomes membrane meningitidis method MHC class mice microbial molecular molecules Mycobacterium Mycobacterium bovis Natl Acad Sci niosomes Nucleic Acids Res particles pathogens peptides phospholipid PLGA potential prediction production protection protein antigens proteins proteome Quil receptors reverse vaccinology saponin signal specific spray drying Springer Science+Business Media stimulation strains structure studies subcellular surface surfactant synthetic T-cell tuberculosis tularensis vaccine adjuvants vaccine antigens vaccine candidates vaccine delivery vaccine design vaccine development vaccine targets Vaxign vesicles virulence factors virus vitro vivo Vordermeier