Immunophysiology: The Role of Cells and Cytokines in Immunity and InflammationJoost J. Oppenheim, Ethan M. Shevach This exciting new text describes how cells normally regulate immunological and inflammatory reactions, and how the immune system is intimately related to other bodily functions. The authors consider the effects of lymphokines on non-inflammatory cells and tissues, including connective tissue and the neuroendocrine system, and describe the effects of neuroendocrine and peptide growth factors produced by non-inflammatory cells and tissues on the functions of immune cells. To highlight the factors regulating immunophysiological functions, they discuss the inflammatory consequences of endotoxin, immune complexes, and complement; the interactions of immunomodulating epidermal factors and immune tissue; the modulation interactions of immunomodulating epidermal factors and immune tissue; and the modulation of immunity by cytokines. The mechanisms by which the immune system normally contends with bacterial, viral or tumor challenges are examined, with an emphasis on basic concepts and key experimental results; and the cells directly involved in host-defense processes are discussed. Wherever possible, information about in vivo and in vitro human immune responses is presented. |
Contents
Structure and Organization of the Lymphatic System | 14 |
Interleukin 2 | 46 |
LymphokineInduced Molecular Signal Transduction | 67 |
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Acad acute-phase anti antibodies antigen binding biochemical Biol biologic blood bone marrow cachectin CD4+ CD8+ cell lines cell surface cell types cellular chemotactic Clin cloned complement complex culture cytes cytokines cytotoxic demonstrated differentiation Dinarello duced effector cells effects endothelial expression fibroblasts function gene GM-CSF helper cells hormones human hybridoma IFNy IL-2 receptor immune response Immunol Immunology induced infection inflammatory inhibit interaction interferon Interleukin keratinocytes leukocytes levels lymph nodes lymphatic lymphocytes lymphoid lymphokines mAbs macrophages mast cells mechanism mediated membrane mice mitogenic molecules monocytes mouse mRNA murine Natl neutrophils NK activity NK cells normal pathway PDGF peptide phages phagocytic phosphorylation PK-C plasma PMNL Proc production proliferation protein regulation release role rophages serum shown soluble specific spleen stimulation studies suppression suppressor suppressor cells synthesis target cell TGFß thymocytes tion tissue viral virus vitro vivo