Immunotherapy with Intravenous Immunoglobulins
Academic Press, Dec 2, 2012 - Medical - 504 pages
The use of intravenous human antibodies in the treatment of primary immunodeficiencies is well recognized. However, it is now evident that they also have therapeutic potential for a wide range of other clinical disorders. This book describes the use of human antibodies in the management of secondary (virus-induced) immunodeficiencies, neonatal and perinatal infections, and autoimmunity. Insight into their mechanism of action is also provided.
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activity acute ANCA anti anti-idiotypic antibiotics antigen autoantibodies autoimmune diseases beneﬁcial beneﬁt blood bone marrow transplantation catabolism cells chronic ITP CIDP Clin clinical conﬁrmed control group cytomegalovirus decreased deﬁciency difﬁcult disorders dose Down’s syndrome effect of IVIG efﬁcacy Engl factor VIII ﬁndings ﬁrst function globulin GVHD hepatitis human hypogammaglobulinemia idiotypic IgG levels IgG subclass immunodeﬁciency Immunol immunological immunosuppressive Immunotherapy Immunotherapy with Intravenous improvement increased infants inﬂammatory inhibition intravenous gammaglobulin intravenous immunoglobulin IVIG IVIG infusion IVIG therapy IVIG treatment Kawasaki Kawasaki disease Lancet lymphocytes mechanisms mg/dl mg/kg monoclonal antibodies months neonates neutrophil normal onset patients Pediatr phase placebo plasma platelet pneumonia post-operative Prednisone preterm prevent production prophylaxis protein reactions receiving IVIG recipients reduced respiratory syncytial virus response Sandoglobulin sepsis septic serum IgG signiﬁcant signiﬁcantly speciﬁc antibody T-cell Table therapeutic thrombocytopenic purpura titers treated trial viral vitro weeks