Immunotoxins

Front Cover
Arthur E. Frankel
Springer Science & Business Media, May 31, 1988 - Medical - 566 pages
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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
 

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Contents

Introduction
1
Toxin Structure
9
Toxin structure
11
Structureactivity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A
25
How Toxins Work
37
How protein toxins enter and kill cells
39
Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes
75
Toxin Selection and Modification
91
Growth factors and other ligands
297
Purification and Chemical Characterization
321
Purification and biochemical characterization of immunotoxins
323
Enhancers
349
19 Immunotoxin enhancers
351
Enhancement of immunotoxin action Manipulation of the cellular routing of proteins
371
Cytotoxicity
391
Methods for quantifying immunotoxin efficacy
393

Toxin selection and modification Overview
93
Toxin selection and modification Utilization of the A chain of ricin
97
Genetic engineering of immunotoxins
113
Diphtheriarelated peptide hormone gene fusions A molecular genetic approach to chimeric toxin development
123
Immunotoxins containing ricin
141
Pseudomonas exotoxin Immunotoxins
161
Immunotoxins containing single chain ribosomeinactivating proteins
175
Covalent Linking Agents
211
Antibodytoxin conjugation
213
Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins
239
Antibody Selection
253
Immunotoxins Selection of cellsurface antigens and their corresponding monoclonal antibodies
255
Nonantibody Ligands
279
Hormone lectin and toxintoxin conjugates
281
Kinetic analysis of cytotoxicity
405
Isolation and analysis of somatic cell mutants resistant to toxin conjugates
417
Animal Studies
431
Immunotoxin therapy Assessment by animal models
433
Prevention of carbohydratemediated clearance of ricincontaining immunotoxins by the liver
457
Human immune response to immunotoxins
475
Clinical Studies
481
Treatment of leukemia patients with T101 ricin A chain immunotoxins
483
Clinical studies Solid tumors
493
Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation
515
Conclusion
537
Index
549
Copyright

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Page 429 - WS, 1983, Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses, Proc. Natl. Acad. Sci. USA 80:5315-5319.
Page 33 - O., and Kato, I. (1968) Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis. J. Biol. Chem. 243, 3553-3555.
Page 33 - Y. (1978) One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 15, 245-250.
Page 121 - Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages, Proc.

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