Impacts of Antibiotic-Resistant Bacteria
Antibiotics provides cures for formerly life-threatening diseases and has prevented many previously inevitable deaths from infected wounds. However, within a short time of each antibiotic's introduction into medicine, some bacteria became resistant to it and the antibiotic lost its effectiveness against some diseases. This report discusses what is known about the emergence and spread of antibiotic-resistant bacteria and describes research aimed at controlling the organisms. 30 charts and tables. Extensive bibliography covering 1950-1994. Glossary of terms.
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Page 156 - have been neither proven nor disproven. The lack of data linking human illness with subtherapeutic levels of antimicrobials must not be equated with proof that the proposed hazards do not exist. The research necessary to establish and measure a definite risk has not been conducted, and, indeed may not be possible.
Page 87 - in journals such as The New England Journal of Medicine and The Journal of the American Medical Association
Page 125 - et al. 1978. Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. Journal of Biological Chemistry
Page 156 - was unable to find a substantial body of direct evidence that established the existence of a definite human health hazard in the use of subtherapeutic concentrations of penicillin and the
Page 124 - BH Park, and SB Levy. 1994. Molecular requirements for the inhibition of the tetracycline antiport protein and the effect of potent inhibitors on the growth of tetracycline-resistant bacteria.
Page 90 - standardized specifications for care developed by a formal process that incorporates the best scientific evidence of effectiveness with expert opinion