In Quest of Tomorrow's Medicines

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Springer Science & Business Media, Jan 14, 2003 - Medical - 272 pages
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An eminent scientist talks about the pharmaceutical industry, biotechnology and the future of drug research. In the course of our busy, technologically-driven lives, it is taken for granted that we respond to minor fluctuations in our health by taking pills -- pills for headache and for toothache; sleeping pills and tranquilizers; pills to lower fever, quiet coughs, and clear the sinuses; medicines to reduce appetite; preparations to relieve heartburn; and many more. In the war against serious disease, medicines are an indispensable weapon in the physician's arsenal: they save lives, or at least prolong them and make them more bearable. Despite the important role that pharmaceuticals play in our lives, few of us know where medicines come from or how the pharmaceutical industry discovers and develops new drugs. Jurgen Drews, an acclaimed leader in the pharmaceutical industry, tells the fascinating story of drug discovery and development from his years of successfully leading internatnional research teams at Hoffman-LaRoche. Drews traces the history of modern drug development from pharmacies, chemical companies, and individual entrepeneurs in Switzerland, Germany and the U.S. to the mega-corporations that dot the landscape of Europe, Japan and America. He describes the process by which new drugs are tested and brought to market, including a provacative look at how AIDS activism stimulated the approval process in the US. Drews' commentary on the role of clinical trials -- the time involved and their cost -- is sobering testimony to the complexity of bringing innovation to the marketplace. In the final two chapters of "In Quest of Tomorrow's Medicines", Drews offers an important and critical analysis of research in the the pharmaceutical industry, pointing to strategies that work and management practices that impede progress. Drews' comments on the impact that the growing relationship between the biotechnology industry and university-sponsored research will have ont he pharmaceutical industry makes provocative reading for pharmaceutical researchers, managers and investors. "In Quest of Tomorrow's Medicines" in written in clear, thoughtful language for people in the pharmaceutical and biotechnology industries, as well as policy makers, industry analysts and observers.
 

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Contents

Drugs Patients and the Pharmaceutical Industry
1
The History of the Pharmaceutical Industry Natural Substances as Drugs
23
Drug Research Merging Experimental Pharmacology and Chemistry
51
Technological Advances and a Paradigm Shift in Drug Research
71
A Medicine Is Born Research Development and Registration
117
Management of Innovation Directing Research and Development
157
The Future of Research and Development in the Pharmaceutical Industry
193
Chapter Notes
237
Glossary
255
Index
263
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About the author (2003)

Jurgen Drews, 1933 in Berlin geboren, studierte Medizin, habilitierte sich und wurde Professor fur Innere Medizin in Heidelberg und Molekulare Genetik in New Jersey, USA. Von 1970 bis 1998 leitete er die weltweite Forschung und Entwicklung grosser international tatiger Pharma-Firmen, zuletzt als Mitglied der Konzernleitung bei Hoffmann-La Roche. Er ist heute freiberuflich tatig und lebt in der Nahe von Munchen und im Tessin. 2004 erhielt er den Beckmann-Preis der American Laboratory Association fur bedeutende Beitrage zur Arzneimittelforschung. Drews veroffentlichte zahlreiche wissenschaftliche Artikel und ist Autor und Herausgeber vieler Fachbucher, z. B. In Quest of Tomorrow's Medicines (Springer, New York, 2000). Daneben publizierte er mehrere Romane, u. a. El Mundo oder die Leugnung der Verganglichkeit (2003), Menschengedenken (2005), Der Spiegelmord im Morderspiel (2006), Wie wir den Krieg gewannen (2007), Jahresringe (2008), Der verschwundene Pianist (2009), Unter der Himmelsuhr (2010), Wendelins Traum (2012) sowie Erzahlungen und Gedichtbande.

John D. Wasnick, MD, MPH
Professor and Chair
Department of Anesthesiology
Texas Tech Health Sciences Center School of Medicine
Lubbock, TX
Zak Hillel, PhD, MD
Professor of Clinical Anesthesiology
Director, Cardiac Anesthesia
St. Luke's-Roosevelt Hospital Center
New York, NY
David Kramer, MD
Assistant Professor
Department of Anesthesiology
St. Luke's-Roosevelt Hospital Center
New York, NY
Sanford Littwin, MD
Assistant Professor
Anesthesiology
St. Luke's-Roosevelt Hospital Center
New York, NY
Alina Nicoara, MD
Assistant Professor
Department of Anesthesiology
Duke University Medical Center
Durham, NC

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