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A General Aspects
Role of Cytokines in Irritant Contact Dermatitis
B In Vitro Approaches
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acid activity allergic alternative animal tests antigen assessment basal cell culture cell lines cellular chemicals classification collagen compounds concentration contact allergens contact dermatitis contact sensitivity correlation CORROSITEX corrosive cosmetic culture medium cutaneous cytokines cytotoxicity dendritic cells dermal irritation Dermatol Dermatology dermis differentiation doses Draize effect endpoints epidermal cells Episkin erythema evaluation exposure factor fibroblasts guinea pigs hapten human epidermal human keratinocytes human skin Immunol incubation induced inflammatory mediators interleukin Invest irradiation irritation potential keratinocytes Langerhans cells layers lipid lymph node lymphocytes MAIBACH measured membrane metabolism microphysiometer molecules murine Neutral Red normal Packing Group patch test PGE2 phototoxicity pollen tubes predict primary proliferation protein reactions release response skin equivalent skin explants skin irritation skin recombinants SKINTEX specific stratum corneum surfactants T-cells test material test substance tissue toxicity Toxicol Toxicology validation vitro assay vitro methods vitro skin vitro test vivo