Induced Effects Of Genotoxic Agents In Eukaryotic Cells

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Toby G Rossman
CRC Press, Sep 21, 1992 - Medical - 167 pages
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Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury.
 

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Contents

Induction of a UV DamageSpecific DNABinding Protein
21
CellCycle and DNADamage Regulation
65
Gene AmplificationA Cellular Response
81
CarcinogenInducible Proteins as Mediators
97
CarcinogenInduced Gene Amplification and Gene
113
gadd 153 a Growth Arrest and DNA Damage Inducible
125
Ultraviolet Irradiation and Phorbol Esters Induce Gene
141
Physical and Chemical Inducers and Inhibitors
163
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