Induction Chemotherapy: Integrated Treatment Programs for Locally Advanced Cancers

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Karl Reinhard Aigner, Frederick O Stephens
Springer Science & Business Media, May 16, 2011 - Medical - 365 pages

Induction chemotherapy, as part of an integrated plan of management for locally advanced cancers, is being practiced throughout the world, but frequently teams are unaware of the work being undertaken in other institutions. This book aims to present the full range of management techniques used in induction chemotherapy within one accessible volume. It provides up-to-date information on pioneering and cutting edge practices and documents the advantages of integrated treatment schedules. Patient selection is discussed, and each of the cancer types for which induction therapy has proved important is considered in detail. All who are responsible for the treatment of patients with locally advanced cancers will find this book to be an invaluable source of information. It will be particularly interesting for specialist oncologists aiming to set up fully comprehensive cancer centers and for health administrators wishing to learn about the benefits of establishing such centers in strategic locations.


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Introduction Overview History Terminology and Early Clinical Experience
The Principle of DoseResponse in Antineoplastic Drug Delivery
Drug Removal Systems and Induction Chemotherapy
Local and Regional Hyperthermia
The Role of Hypoxia and Hyperthermia in Chemotherapy
Induction Chemotherapy in Head and Neck Cancers
Isolated Thoracic Perfusion with Carotid Artery Infusion for Advanced and Chemoresistant Tumors of the Parotid Gland
Isolated Limb Perfusion for Melanoma
Interventional Radiological Procedures for PortCatheter Implantation
Induction Chemotherapy for Hepatocellular Carcinoma
Systemic Induction Chemotherapy for Advanced Stage Epithelial Ovarian Cancer
Induction Chemotherapy for Cervical Cancer
Induction Treatment in Sarcomas
Induction Chemotherapy in Treatment of Sarcomas
Liver Metastases

Induction Systemic Chemotherapy for Breast Cancer
Induction Intraarterial Chemotherapy IAC with Epirubicin and Mitoxantrone in Locally Advanced Breast Cancer
Induction Bidirectional Chemotherapy for Gastric Cancer with Peritoneal Dissemination
Gastric Cancer
Esophageal Cancer
Regional Chemotherapy for Recurrent Platin Refractory Ovarian Cancer
Penile Cancer Treated by Intraaortic Infusion Chemotherapy
Isolated Thoracic Perfusion with Chemofiltration ITPF for Advanced and Pretreated NonSmallCell Lung Cancer
Isolation Perfusion Systems Lungs
Metastatic Cancers in Lung Isolated Lung Perfusion Clinical Studies
Systemic and Regional Chemotherapy for Advanced and Metastasized Pancreatic Cancer

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About the author (2011)

Prof. Dr. med. Karl Reinhard Aigner is Medical Director of the Department of Surgical Oncology in Medias Klinikum Burghausen, Bavaria. He had his surgical training in cardiovascular surgery at Friedrich-Alexander University in Erlangen. At Justus-Liebig University Giessen he specialized in surgical oncology, focusing on vascular techniques of drug delivery such as Implantofix and Jet Port catheters, and in 1981 first performed a technique of isolated perfusion of the liver with heart-lung machine in man. Furtheron he developed various techniques of segmental vascular isolation of body segments and organs, and the stopflow technique with adequately designed catheters. In 1982, together with Prof. Stephens from Sydney, he initiated the biannual International Congress of Regional Cancer Treatment (ICRCT) and from 1987 to 1991 was president of the International Society for Regional Cancer Therapy. From 1985 to 1998 he was managing editor of the International Journal Regional Cancer Treatment. He is author of numerous publications and book chapters, lectured and performed teaching operations on vascular perfusion techniques and oncological surgery in Europe the United States and Asia.

Frederick Oscar Stephens (MD, MS FRCS (Ed), FACS, FRACS) is former Professor of Surgical Oncology and Head of Department of Surgery, The University of Sydney, Australia. With other colleagues in Europe, UK, North America, South Africa, India, Japan and Tawain he has been a pioneer in the development of the principles of using integrated treatment modalities in management of locally advanced cancers. Advanced malignancies in limbs that previously required limb amputation can now be treated equally effectively without amputation in about 80% of patients. Oncologists in many cancer clinics worldwide are now achieving similarly improved results from the application of similar techniques and principles. He was the founding president of The International Society for Regional Cancer Therapy (1982) and has lectured extensively on regional cancer treatment and surgical oncology in Germany, Austria, France, England, Scotland, Wales, Ireland, America, Canada, Israel, Greece, Hungary, Japan and New Zealand as well as in his home country of Australia. He is the author of over 200 publications in medical journals, several book Chapters and two theses. Since retirement he has authored 4 books on cancers in general and specific cancers for lay people, and with Professor Aigner and other world experts has written The Basics of Oncology, a text for medical and paramedical practitioners and nurse oncologists. A little known international surgical contribution of Professor Stephens is that when he was a Senior Surgical Registrar in training in Aberdeen Scotland with Professor Hugh Dudley, he published the first paper on Outpatient Surgery under general anaesthesia in adults in Lancet 1961. Outpatient (Day Stay or Ambulatory Surgery) techniques and policy have now become standard practice worldwide making great savings in health budgets the world over.

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