Induction and Analysis of Antigen-Specific T Cell Responses in Melonoma Patients and Animal Models

Front Cover
Amsterdam University Press, 2007 - Health & Fitness - 152 pages
Annotation. In the last century, it has become clear that in patients suffering certain types of cancer, spontaneous activation of the immune sytem may lead to curation. The concept of immunotherapy is based on that notion. The intention is to stimulate T cells directed against the cancer, leading to the eradication of cancer cells. However, the methods to stimulate T cell immunity are just evolving, and at the moment they are functional in small laboratory animals only. Furthermore, we know now that many cancer cells possess the capacity to scive attacks of the immune system. This thesis introduces a novel T cell vaccination method that uses a tattoo machine to inject DNA in the skin of the vaccinee. In comparison to other experimental vaccination methods DNA tattooing is very strong: besides small laboratry animals also large animals (mockeys) mount strong T cell responses on tattoo DNA vaccination. Future tests in melanoma patients will point out whether DNA tattoo vaccination is equally efficient in humans, and whether it may have a therapeutic effect in these patients. This title can be previewed in Google Books - http://books.google.com/books?vid=ISBN9789087280116.
 

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Contents

Introduction
9
On the Role of MelanomaSpecific CD8+ TCell Immunity in Disease Progression of AdvancedStage Melanoma Patients
24
Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GMCSF in advancedstage HLAA0201 positive melanom...
43
A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression
57
Superior immunogenicity of DNA tattooing as compared to intramuscular DNA vaccination in nonhuman primates
72
In vivo antigen stability affects vaccine efficacy
82
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing
104
Design and use of conditional MHC class I ligands
118
Discussion
138
Dutch Summary
147
Acknowledgements and Curriculum Vitae
148
Copyright

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