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Theoretical study of monooxygenase catalyzed oxidations and their models
Bioorganic mechanisms of the metabolism of dihalomethanes to carbon
The role of the lung in the metabolism and disposition of xenobiotics T
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acid Acta administration aminopyrine aniline animals antipyrine benzene benzo(a)pyrene benzphetamine Biochem Biol Biophys biotransformation blood carbon carcinogenic cells Chem chemical cholesterol clearance complex compounds concentration conjugation correlation covalent binding cytochrome P-450 decrease determined dose drug metabolism effect enzyme enzyme activity epoxide ethanol ethylmorphine excretion experiments exposure formation fraction glutathione halothane hepatic hepatic microsomes hepatocytes homogenates human liver hydrocarbons hydroxylase hydroxylation increased incubation induced inhibition interaction isolated kidney kinetic lipid peroxidation lipophilic liver lung male membranes metabolites METHODS metyrapone mg/kg mice microsomal protein microsomes molecular monooxygenase NADPH obtained oxygen paraquat PCBs perfused Pharmacol phenobarbital pretreatment product adduct radioactivity rat liver microsomes reactions reactive reductase samples solvents species spectral styrene styrene oxide substrate Table tion tissue toxic Toxicol trichloroethylene uptake urine vinyl chloride vitro vivo Wistar rats xenobiotics