Inflammation and Gastrointestinal Cancers

Front Cover
Janusz A. Z. Jankowski
Springer Science & Business Media, Aug 8, 2011 - Medical - 202 pages

Inflammation in gastrointestinal mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it has fundamental clinical consequences, the principal of which is premalignant metaplasia throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for GI cancer.

This book discusses all aspects of the relation between inflammation and GI cancer, from the basic science through to the translational science which is helping in the optimization of clinical management strategies. Among the topics considered are the impact of inherited syndromes; the roles of acid reflux, H. pylori, inflammatory bowel disease, and primary sclerosing cholangitis; screening strategies; targeted drug therapies; genetics; and the use of endoscopic methods. The authors are the best in their field, and this book is designed for the enthusiastic student as well as the professional in GI science and medicine.

 

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Contents

2 Inherited Syndromes Predisposing to Inflammation and GI Cancer
35
3 Stem Cells and Inflammation in the Intestine
51
4 Acid Reflux and Oesophageal Cancer
65
5 Helicobacter pylori and Gastric Cancer
83
6 Inflammatory Bowel Disease and Colon Cancer
98
7 Primary Sclerosing Cholangitis
117
8 Chronic Inflammation and Hepatocellular Carcinoma
134
Current Screening Strategies
149
10 Targeted Drug Therapies and Cancer
159
11 Genetics of Inflammation in the Gastrointestinal Tract and How it Can Cause Cancer
172
12 Endoscopic Methods
185
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