Inflammation and Rheumatic Diseases: The Molecular Basis of Novel Therapies
Georg Thieme Verlag, 2003 - Anti-inflammatory agents - 139 pages
This book is a useful guide for students, physicians in continuing education and practitioners who want to keep abreast of the latest developments in rheumatology. The chapters on the pathogenesis of rheumatoid arthritis and the biochemistry of inflammation present the latest research results in this field and are illustrated by a wealth of charts and tables. There follows practical and critical information on all drug groups that are currently used in the treatment of inflammatory rheumatic diseases and osteoarthritis. (Midwest).
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5-lipoxygenase acetaminophen activity adverse effects analgesic anti-in anti-inflammatory drugs antibodies antigens arachidonic acid Arthritis Rheum aspirin Biol Chem biosynthesis blood cartilage celecoxib cells chronic Clin clinical COX-1 and COX-2 COX-2 inhibitors coxibs cyclooxygenase cyclooxygenase-2 cytokines diagnosis diclofenac disease dosage dose enzymes factor fects fibroblasts function gastric gastrointestinal gene glucocorticoids half-life human ibuprofen Immunol increased indomethacin induced inflammation inflammatory inhibition involvement isoforms joint destruction kidneys leukocytes leukotriene licofelone Lipoxins LTA4 LTB4 LTC4 LTD4 LXA4 macrophages Mechanisms of action mediators membrane metabolism methotrexate mg/kg mice monocytes mucosa naproxen nonsteroidal NSAIDs onset oral osteoarthritis pain pathway patients peripheral PGD2 PGE2 PGI2 Pharmacol phospholipase A2 PLA2 plasma platelet potent production prosta prostaglandin prostanoids protein psoriatic rats receptor renal rheumatoid arthritis rofecoxib role SAARDs selective COX-2 side effects specific studies synovial synovium synthase synthesis therapeutic therapy thromboxane tion tissue tive TNF-a treatment tumor TXA2 ulcers vascular vivo