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FK506 A NEW IMMUNOSUPPRESSIVE AGENT
EFFECTS OF FK506 ON OTHER CELL TYPES
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24 hours 72 hours 96 hours a-chain A-stimulated adherence ampoule antibodies antigen assay autoimmune binding Biochem blood calcineurin cell adhesion molecule cell types cells/ml Clin clinical concentrations coworkers CsA and FK506 CsA or FK506 culture cyclophilin cyclosporin cytokine decrease drug E-selectin effects of FK506 endothelial cells endothelium expression Figure FK506 inhibits FK506 treatment FKBP flow cytometry granulocytes heat output heat production hours of incubation human lymphocytes HUVEC IL-2 receptor Immunol Immunology immunophilins immunosuppressive agent incubation hours induced inflammatory inhibitory effect integrin interactions interleukin-2 receptor intracellular isolated Karlsson leukocyte Lund lymphocyte adhesion lymphocytes mediators medium membrane metabolism mitochondrial mitogen mitogen stimulation mitogen-stimulated lymphocytes monitoring monoclonal Nassberger neutrophilic ng/ml Proc proliferation propidium iodide protein release reported resting cells resting lymphocytes selectin signal significantly soluble Starzl stimulated cells stimulated lymphocytes subunits Sweden T-cell T-cell activation TNF-a transplantation up-regulation uptake vitro vitronectin