Inorganic and Organic Lead Compounds
International Agency for Research on Cancer, Jan 1, 2006 - Medical - 506 pages
The 87th volume of IARC monographs contains evaluations of inorganic and organic lead components. Lead salts and organic lead compounds were considered by the IARC Monographs Working Groups. Since 1987, new epidemiological and experimental studies have become available. Lead is found at low concentrations in the earth's crust, predominantly as lead sulfide, but the widespread occurrence of lead in the environment is largely the result of human activity. As a result, human exposure to lead is universal, and all humans carry a body burden of lead. Lead has long been of concern for its adverse health effects other than cancer, in particular its neuro-development effects on the fetus, infants, and children. These health effects are discussed in this volume in some detail. The main focus of this monograph is on the epidemiological studies and experimental investigations attempting to determine whether exposure to lead is associated with the development of some forms of cancer.
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Studies of Cancer in Experimental Animals
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absorption acid adenomas adults analysis animals arsenic blood lead concentrations calcium carcinogenicity case—control study cells chemical China cohort concen concentrations of lead containing contd controls countries deaths decreased Development Association International diet dietary dose drinking-water effects of lead Environ Evaluation excretion exposed exposure to lead female gasoline gliomas Group noted Gulson Health humans IARC increased India industrial inorganic lead intake Japan kidney lead acetate lead chromate lead compounds Lead Development Association lead exposure lead oxide lead poisoning lead smelter lead subacetate lead-exposed Lead–acid battery lung cancer male mean blood lead metal mg/kg bw mice milk mortality NIOSH observed occupational exposure odds ratio phytoextraction pig/dL plants plasma population range relative risk renal tumours reported samples significant smelter smelter workers soil source of lead stomach cancer subcohort Table tetraethyl lead tissues trations ug/dL ug/L ug/m unspecified women Year(s zinc