Pedro Cuatrecasas, Steven Jacobs, J. Avruch
Springer-Verlag, Jan 1, 1990 - Insulin - 474 pages
This volume reviews selected areas of insulin pharmacology, including insulin chemistry, structure, secretion by beta cells, receptor interaction, molecular biology and cellular responses. The reviews are authoritative and up-to-date. It maintains a manageable size in spite of the extent of the subject covered, by focussing on areas that have made particularly rapid progress in recent years, and reviewing these in broad yet concise fashion.
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Chemical Synthesis of Insulin Analogs
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abnormal insulin Acad Sci USA adipocytes affinity allele amino acid analogs antibodies autophosphorylation Biochem Biophys Res Biol Chem biological activity Biophys Res Commun biosynthesis Ca2+ casein kinase cellular cleavage COOH terminal cyclic AMP cytosolic decreased degradation Diabetes dimer Dodson domain effects of insulin enzyme glucagon gluconeogenesis glycogen synthase hepatocytes hexamer hormone hyperpolarization IGF-I increase inhibition insulin action insulin analogs insulin molecule insulin receptor insulin receptor kinase insulin release insulin-like growth factor insulin-stimulated intact interaction intracellular islet cells isolated Kahn CR kinase activity Malaisse WJ mediator metabolism mRNA mutant insulin Natl Acad Sci normal ofthe pancreatic peptide phosphatase phosphodiesterase phospholipase phosphorylation plasma membrane polypeptide precursor Proc Natl Acad processing proinsulin protease protein kinase purified region regulation residues role Rubenstein AH secretion semisynthesis sequence SHOELSON side chains specific ß cells ß subunit Steiner DF stimulation structure studies substrate sulin synthesis Tager HS tion tissue transcription tyrosine kinase vitro