Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics

Front Cover
Derek LeRoith
Springer Science & Business Media, Sep 18, 2011 - Medical - 284 pages
The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
 

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Contents

Epidemiology of IGF1 and Cancer
1
Aging and Cancer The IGFI Connection
25
Obesity Type 2 Diabetes and Cancer
37
IGF System and Breast Cancer
73
The Role of InsulinLike Growth Factor Signaling in Prostate Cancer Development and Progression
85
IGF1 Cellular Action and its Relationship to Cancer Evidence from in Vitro and in Vivo Studies
105
InsulinLike Growth Factor Signaling in Pediatric Sarcomas
147
Cancer Genes Tumor Suppressors and Regulation of IGF1R Gene Expression in Cancer
159
Mouse Models of IGF1R and Cancer
178
Targeting the InsulinLike Growth FactorI Receptor in Cancer Therapy
193
Targeting InsulinLike Growth Factor Receptor 1 IGF1R and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer
214
Calories and Cancer The Role of InsulinLike Growth Factor1
231
Cancer Cell Metabolism
244
Overlaps Between the Insulin and IGFI Receptor and Cancer
263
Index
279
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