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2-5A synthetase Acad adjuvant administration antibody antigen antitumor activity antitumor effect antiviral Balkwill Biochem breast carcinoma Cancer Inst Cantell cell lines chemotherapy clinical trials clone colon cancer culture cytotoxic disease drug dsRNA effect of IFN effects of interferon enhanced enzyme fibroblast fibroblast interferon gene genital warts Gresser Gutterman histological human fibroblast human interferon human leukocyte interferon human lymphoblastoid IFN treatment IFN-a Ikid immune increased inhibition inhibitory effect initial injection interferon inducers interferon preparations interferon therapy interferon treatment juvenile laryngeal laryngeal papillomas laryngeal papillomatosis lesions leukemia levels lymphoblastoid lymphocytes lymphokines lymphoma macrophages malignant Merigan metastases Methods in Enzymology mouse interferon multiple multiple myeloma murine myeloma Natl natural killer cells NK cells osteosarcoma papillomatosis phase poly ICLC Proc production protein kinase purified recombinant regression reported response Sendai virus serum Strander studies tissue Tovey toxicity transplantable treated tumor cells tumor growth viral viruses vitro vivo weeks