Interferons: mechanisms of action and role in cancer therapy
A great deal of new information has been obtained during the past four years, and this monograph provides a clear and well reviewed update on biochemical mechanisms and the results of important new clinical studies using the interferons. Reviews include what is presently known about the biosynthesis, physiological role and mechanisms of action of the interferons (alpha, beta, gamma). New biochemical information on interferon-receptor interactions and signalling pathways is provided. The pharmacokinetic considerations in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and other solid tumors are reviewed with special emphasis on studies of adjuvant chemotherapy in malignancies of the immune system.
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Biosynthesis Physiological Roles
The Role of lnterferon in the Management of LowGrade Lymphoma
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Interferons: Mechanisms of Action and Role in Cancer Therapy
No preview available - 2012
activity Alpha interferon antigens antitumour effects antiviral beta lFN binding biochemical breast cancer carcinoid syndrome carcinoid tumours cDNA cell lines chemotherapy chlorambucil chromosome Clin Oncol clinical cloned combination cytokines cytotoxic demonstrated disease dose drug dsRNA endocrine pancreatic tumours evaluable expression feron figs fluorouracil follicular lymphoma gamma lFN growth factors hairy cell leukaemia Hardcover lSBN hormone human leukocyte interferon induced infection inhibit inter interferon-alpha interferon-gamma leukaemia leukocyte lFN genes lFN-alpha lnduction lSREs malignant carcinoid tumours Mechanisms of Action median melanoma Mellstedt melphalan metastatic MGCS monoclonal months MP/lFN multiple myeloma mycosis fungoides neuroendocrine tumours non-Hodgkin's lymphoma number of patients Oberg Oncology pathway patients treated phase ll study Proc protein randomised receptor recombinant interferon regulatory remission renal cell carcinoma response rate role signal single agent sponse streptozotocin survival symptoms tients tion toxicity transcription trial tumour cells type l lFNs viral virus viruses vitro vivo