Interferons: mechanisms of action and role in cancer therapy
A great deal of new information has been obtained during the past four years, and this monograph provides a clear and well reviewed update on biochemical mechanisms and the results of important new clinical studies using the interferons. Reviews include what is presently known about the biosynthesis, physiological role and mechanisms of action of the interferons (alpha, beta, gamma). New biochemical information on interferon-receptor interactions and signalling pathways is provided. The pharmacokinetic considerations in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and other solid tumors are reviewed with special emphasis on studies of adjuvant chemotherapy in malignancies of the immune system.
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Biosynthesis Physiological Roles
The Role of Interferon in the Management of LowGrade Lymphoma
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Interferons: Mechanisms of Action and Role in Cancer Therapy
No preview available - 2012
activity alpha interferon antigens antitumour effects antiviral Balkwill beta IFN binding biochemical Biol breast cancer Cancer Res carcinoid syndrome carcinoid tumours cDNA cell lines chemotherapy chlorambucil chromosome clinical cloned combination cytokines cytotoxic effect disease dose doxorubicin drugs dsRNA duration endocrine pancreatic tumours evaluation expression feron figs fluorouracil follicular lymphoma gamma IFN Group growth factors hairy cell leukaemia Hardcover ISBN hormone human leukocyte interferon IFN genes IFN-alpha induced infection inhibit inter interferon alfa-2b interferon therapy interferon-alpha interferon-gamma interleukin-2 leukaemia leukocyte malignant carcinoid tumours Mechanisms of Action median melanoma Mellstedt melphalan metastatic MGCS MP/IFN multiple myeloma neuroendocrine tumours non-Hodgkin's lymphoma nude mice number of patients Oberg Oncology pathway patients treated phase I study Proc protein randomised receptor recombinant interferon remission renal cell carcinoma response rate role signal single agent sponse streptozotocin survival symptoms tients tion toxicity transcription trial tumour cells viral virus viruses vitro vivo xenografts